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Showing 1–3 of 3 results
Advanced filters: Author: Tao-Hsin Chang Clear advanced filters

  • The Wnt receptor Frizzled (FZD) family is crucial for both canonical (β-catenin dependent) and non-canonical (β-catenin independent) Wnt signalling. Here, the authors present the structures of FZD3 in complex with extracellular and intracellular binding nanobodies (Nbs), elucidating extracellular and intracellular interaction surfaces of functional and potentially therapeutic significance.

    • James Hillier
    • Yuguang Zhao
    • E. Yvonne Jones
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-13

  • The biochemical activity of Notum as a carboxylesterase that removes an essential lipid moiety from Wnt proteins is uncovered; the interaction of Notum with glypicans is required to ensure localization at the cell surface, and Notum may provide a new target for therapeutic development in diseases with defective Wnt signalling.

    • Satoshi Kakugawa
    • Paul F. Langton
    • Jean-Paul Vincent
    Research
    Nature
    Volume: 519, P: 187-192