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Showing 1–4 of 4 results
Advanced filters: Author: Tara Soumerai Clear advanced filters

  • How different oncogenic Akt mutants can affect the response to Akt inhibitors is currently unclear. Here, the authors analyse somatic mutations of Akt1-3 isoforms in several human cancers, investigate their oncogenic effects and therapeutic relevance in vitro and confirm some of their data in a clinical trial testing the AKT inhibitor capivasertib in patients with solid tumors harboring AKT alterations.

    • Tripti Shrestha Bhattarai
    • Tambudzai Shamu
    • Barry S. Taylor
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-11

  • MSK-IMPACT is a clinical sequencing platform able to detect genomic mutations, copy number alterations and structural variants in a panel of cancer-related genes. This assay is implemented prospectively to inform patient enrollment in genomically matched clinical trials at Memorial Sloan Kettering Cancer Center (MSKCC). Sequencing results of tumor and matched normal tissue from a cohort of >10,000 patients with detailed clinical annotation provide an overview of the genomic landscape of advanced solid cancers and bring new insights into molecularly guided cancer therapy.

    • Ahmet Zehir
    • Ryma Benayed
    • Michael F Berger
    Research
    Nature Medicine
    Volume: 23, P: 703-713