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Showing 1–3 of 3 results
Advanced filters: Author: Tara Wilmot Clear advanced filters

  • CAR T cell success requires targeting tumors, but these cells can get trapped in other tissues, such as in the lungs, where they can cause pathology. Here, the authors use a loss-of-function CRISPR screen to identify regulators of CAR T cell tumor trafficking and engineer CAR T cells accordingly to overcome this limitation.

    • Yeonsun Hong
    • Brandon L. Walling
    • Minsoo Kim
    Research
    Nature Immunology
    Volume: 24, P: 1007-1019

  • Analyses of samples from patients with acute myeloid leukaemia reveal that drug response is associated with mutational status and gene expression; the generated dataset provides a basis for future clinical and functional studies of this disease.

    • Jeffrey W. Tyner
    • Cristina E. Tognon
    • Brian J. Druker
    Research
    Nature
    Volume: 562, P: 526-531

  • Fibre snacks that target distinct features of the microbiomes of donors with obesity transplanted into gnotobiotic mice also lead to fibre-specific changes in the microbiome and physiology when used in controlled-diet human studies.

    • Omar Delannoy-Bruno
    • Chandani Desai
    • Jeffrey I. Gordon
    Research
    Nature
    Volume: 595, P: 91-95