Saeedi Saravi and colleagues demonstrate an age-related increase in the gut microbial metabolite phenylacetic acid (PAA) in humans and mice, linked to Clostridium bacteria. In mice, they find that PAA triggers endothelial senescence, linking the microbiome to vascular aging.
- Seyed Soheil Saeedi Saravi
- Benoit Pugin
- Jürg H. Beer
