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Lipid remodeling in megakaryocyte differentiation and platelet biogenesis

Lipid remodeling, from fatty acid transport and de novo lipid synthesis, is necessary for megakaryocyte differentiation and platelet production. Dietary saturated fatty acids, impaired fatty acid transport and/or dysfunction in lipid biogenesis can contribute to low platelet counts.

Kanika Jain
Tarun Tyagi
John Hwa
News & Views04 Sept 2023
Nature Cardiovascular Research

Volume: 2, P: 803-804
Comparison of efficacy and safety of various management options for large upper ureteric stones a systematic review and network meta-analysis

Gopal Sharma
Tarun Pareek
Sudheer Kumar Devana
ResearchOpen Access03 Jun 2021
Scientific Reports

Volume: 11, P: 1-9
CELA2A mutations predispose to early-onset atherosclerosis and metabolic syndrome and affect plasma insulin and platelet activation

Exome sequencing identifies loss-of-function CELA2A mutations in families with early-onset atherosclerosis and metabolic syndrome. Functional studies show that CELA2A is a circulating enzyme that reduces platelet activation, triggers insulin secretion and degradation, and increases insulin sensitivity.

Fatemehsadat Esteghamat
James S. Broughton
Arya Mani
Research29 Jul 2019
Nature Genetics

Volume: 51, P: 1233-1243
A guide to molecular and functional investigations of platelets to bridge basic and clinical sciences

In this Review, Hwa and colleagues summarize the latest advances in platelet biology and function and appraise the technical and biological challenges in platelet investigations.

Tarun Tyagi
Kanika Jain
John Hwa
Reviews03 Mar 2022
Nature Cardiovascular Research

Volume: 1, P: 223-237
Rational truncation of aptamer for cross-species application to detect krait envenomation

Abhijeet Dhiman
Anjali Anand
Tarun Kumar Sharma
ResearchOpen Access12 Dec 2018
Scientific Reports

Volume: 8, P: 1-8
Thrombocytopathy and endotheliopathy: crucial contributors to COVID-19 thromboinflammation

This Review summarizes the latest evidence indicating that platelet and endothelial dysfunction are essential components of COVID-19 pathology, describes the potential mechanisms underlying the contribution of cardiovascular risk factors to the most severe outcomes in COVID-19, and highlights the roles of coagulopathy, thrombocytopathy and endotheliopathy in COVID-19 pathogenesis.

Sean X. Gu
Tarun Tyagi
John Hwa
Reviews19 Nov 2020
Nature Reviews Cardiology

Volume: 18, P: 194-209

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Lipid remodeling in megakaryocyte differentiation and platelet biogenesis

Comparison of efficacy and safety of various management options for large upper ureteric stones a systematic review and network meta-analysis

CELA2A mutations predispose to early-onset atherosclerosis and metabolic syndrome and affect plasma insulin and platelet activation

A guide to molecular and functional investigations of platelets to bridge basic and clinical sciences

Rational truncation of aptamer for cross-species application to detect krait envenomation

Thrombocytopathy and endotheliopathy: crucial contributors to COVID-19 thromboinflammation

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