Mycobacterium tuberculosis has a proteasome similar to eukaryotes. This study reveals how the activator Bpa recruits its substrate HspR, providing structural and mechanistic insights. The authors identify key Bpa residues involved in substrate binding, shedding light on the Bpa-proteasome pathway.
- Tatjana von Rosen
- Rafal Zdanowicz
- Eilika Weber-Ban