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Showing 1–2 of 2 results
Advanced filters: Author: Tatsuki Nonomura Clear advanced filters

  • Store-operated Ca2+ entry is essential for cellular signalling, yet excessive calcium influx drives disease. Here, authors develop genetically encoded CRAC channel inhibitory binders (CRABs) to precisely modulate Ca2+ signalling, with therapeutic potential in channelopathies and cancer immunotherapy.

    • Xiaoxuan Liu
    • Sher Ali
    • Yubin Zhou
    ResearchOpen Access
    Nature Communications
    Volume: 17, P: 1-19

  • There remains a demand for optogenetic tools that provide modularity, ease of integration, and minimal interference with protein function. Here, authors introduce PhoBITs as compact and modular optogenetic tools for reversible control, demonstrating a range of applications including in vivo optogenetic tumor suppression.

    • Yi-Tsang Lee
    • Lei Guo
    • Yubin Zhou
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-18