Nature Search

Lineage-dependent variations in single-cell antibiotic susceptibility reveal the selective inheritance of phenotypic resistance in bacteria

Prior work on antibiotic resistance focused on genetic changes. In this work, authors analysed heterogeneous responses of isogenic bacterial cells to antibiotics, revealing heritable phenotypic resistance that selectively enriches robust lineages in populations.

Wesley Stine
Tatsuya Akiyama
Minsu Kim
ResearchOpen Access19 May 2025
Nature Communications

Volume: 16, P: 1-9
Drought recovery in plants triggers a cell-state-specific immune activation

Post-drought rehydration triggers a preventive immune response in plants, revealing targets to enhance crop resilience by linking drought stress recovery with improved pathogen resistance.

Natanella Illouz-Eliaz
Jingting Yu
Joseph R. Ecker
ResearchOpen Access29 Aug 2025
Nature Communications

Volume: 16, P: 1-15
Exploring nonequilibrium phases of photo-doped Mott insulators with generalized Gibbs ensembles

Light-matter interactions can induce phases and physics not observable in the equilibrium regime of a quantum material but understanding the underlying mechanisms can be challenging. Here, the authors show a generalised Gibbs ensemble applied to photo-doped states in Mott insulators can be used to investigate the non-thermal phases of various correlated states.

Yuta Murakami
Shintaro Takayoshi
Philipp Werner
ResearchOpen Access13 Jan 2022
Communications Physics

Volume: 5, P: 1-8
iPS-cell-derived microglia promote brain organoid maturation via cholesterol transfer

The authors seek to understand the precise roles of microglia in the early human brain by coculturing brain organoids with primitive-like macrophages generated from the same human induced pluripotent stem cells (iMac).

Dong Shin Park
Tatsuya Kozaki
Florent Ginhoux
Research01 Nov 2023
Nature

Volume: 623, P: 397-405
Sampling, identification and sensory evaluation of odors of a newborn baby’s head and amniotic fluid

Tatsuya Uebi
Takahiko Hariyama
Mamiko Ozaki
ResearchOpen Access04 Sept 2019
Scientific Reports

Volume: 9, P: 1-11
Long intervals between repetitive concussions reduce risk of cognitive impairment and limit microglial activation, astrogliosis, and tauopathy in adolescent rats

Yuichi Hirata
Kyohei Kin
Shota Tanaka
ResearchOpen Access18 Nov 2025
Scientific Reports

Volume: 15, P: 1-12
Hyperosmotic tolerance of adult fish and early embryos are determined by discrete, single loci in the genus Oryzias

Taijun Myosho
Hideya Takahashi
Mitsuru Sakaizumi
ResearchOpen Access02 May 2018
Scientific Reports

Volume: 8, P: 1-8
A predictive computational platform for optimizing the design of bioartificial pancreas devices

Transplanting encapsulated insulin-producing cells may achieve a functional cure for type 1 diabetes, but efficacy is constrained by mass transfer limits. Here, the authors report a dynamic computational platform to investigate the therapeutic potency of such programmable bioartificial pancreas devices.

Alexander U. Ernst
Long-Hai Wang
Minglin Ma
ResearchOpen Access13 Oct 2022
Nature Communications

Volume: 13, P: 1-18
Glucose-dependent partitioning of arginine to the urea cycle protects β-cells from inflammation

β-cell dysfunction in diabetes is caused by glucose and inflammation toxicity. Here, Fu et al. show that β-cell glucose metabolism can be protective though pyruvate carboxylase–mediated shunting of arginine to ureagenesis and away from toxic nitric oxide production, thus suppressing inflammation.

Accalia Fu
Juan Carlos Alvarez-Perez
Nika N. Danial
Research11 May 2020
Nature Metabolism

Volume: 2, P: 432-446
A prevascularized subcutaneous device-less site for islet and cellular transplantation

Diabetes reversal in mice is achieved by transplanting islets into a prevascularized space under the skin.

Andrew R Pepper
Boris Gala-Lopez
A M James Shapiro
Research20 Apr 2015
Nature Biotechnology

Volume: 33, P: 518-523
Blood pressure during long-term cilostazol-based dual antiplatelet therapy after stroke: a post hoc analysis of the CSPS.com trial

Kazunori Toyoda
Masatoshi Koga
Hiroaki Tanaka
ResearchOpen Access09 Jul 2024
Hypertension Research

Volume: 47, P: 2238-2249
Clarifying social norms which have robustness against reputation costs and defector invasion in indirect reciprocity

Hitoshi Yamamoto
Isamu Okada
Satoshi Uchida
ResearchOpen Access23 Oct 2024
Scientific Reports

Volume: 14, P: 1-8
Information aggregation and collective intelligence beyond the wisdom of crowds

Collective intelligence emerges in group decision-making, whether it requires a consensus or not. In this Review, Kameda et al. describe cognitive and behavioural algorithms that capitalize on individual heterogeneity to yield gains in decision-making accuracy beyond the wisdom of crowds.

Tatsuya Kameda
Wataru Toyokawa
R. Scott Tindale
Reviews25 Apr 2022
Nature Reviews Psychology

Volume: 1, P: 345-357
CD82 is a marker to isolate β cell precursors from human iPS cells and plays a role for the maturation of β cells

Ami Watanabe
Anna Tanaka
Atsushi Miyajima
ResearchOpen Access05 May 2021
Scientific Reports

Volume: 11, P: 1-12
Majority rule can help solve difficult tasks even when confident members opt out to serve individual interests

Kiri Kuroda
Mayu Takahashi
Tatsuya Kameda
ResearchOpen Access08 Sept 2023
Scientific Reports

Volume: 13, P: 1-10
Single-cell analyses of human islet cells reveal de-differentiation signatures

Adrian Keong Kee Teo
Chang Siang Lim
Hwee Hui Lau
ResearchOpen Access09 Feb 2018
Cell Death Discovery

Volume: 4, P: 1-11
Cell encapsulation enhances antidepressant effect of the mesenchymal stem cells and counteracts depressive-like behavior of treatment-resistant depressed rats

Kyohei Kin
Takao Yasuhara
Isao Date
Research14 Aug 2018
Molecular Psychiatry

Volume: 25, P: 1202-1214
Cervical spinal cord stimulation exerts anti-epileptic effects in a rat model of epileptic seizure through the suppression of CCL2-mediated cascades

Yosuke Okazaki
Tatsuya Sasaki
Isao Date
ResearchOpen Access24 Jun 2024
Scientific Reports

Volume: 14, P: 1-10
Influence of hospital capabilities and prehospital time on outcomes of thrombectomy for stroke in Japan from 2013 to 2016

Ai Kurogi
Daisuke Onozuka
Masayuki Yokota
ResearchOpen Access28 Feb 2022
Scientific Reports

Volume: 12, P: 1-17
Silencing the G-protein coupled receptor 3-salt inducible kinase 2 pathway promotes human β cell proliferation

Caterina Iorio et al. use a high-throughput RNAi screen to identify the GPR3-SIK2-CDKN1B axis as key players involved in regulating pancreatic beta cell proliferation. These results suggest that GPR3 and SIK2 are both potential targets to stimulate regeneration of beta cells in diseases like type 1 diabetes.

Caterina Iorio
Jillian L. Rourke
Robert A. Screaton
ResearchOpen Access23 Jul 2021
Communications Biology

Volume: 4, P: 1-13
Ferroptosis-inducing agents compromise in vitro human islet viability and function

Antonio Bruni
Andrew R. Pepper
A. M. James Shapiro
ResearchOpen Access22 May 2018
Cell Death & Disease

Volume: 9, P: 1-10

Search

Lineage-dependent variations in single-cell antibiotic susceptibility reveal the selective inheritance of phenotypic resistance in bacteria

Drought recovery in plants triggers a cell-state-specific immune activation

Exploring nonequilibrium phases of photo-doped Mott insulators with generalized Gibbs ensembles

iPS-cell-derived microglia promote brain organoid maturation via cholesterol transfer

Sampling, identification and sensory evaluation of odors of a newborn baby’s head and amniotic fluid

Long intervals between repetitive concussions reduce risk of cognitive impairment and limit microglial activation, astrogliosis, and tauopathy in adolescent rats

Hyperosmotic tolerance of adult fish and early embryos are determined by discrete, single loci in the genus Oryzias

A predictive computational platform for optimizing the design of bioartificial pancreas devices

Glucose-dependent partitioning of arginine to the urea cycle protects β-cells from inflammation

A prevascularized subcutaneous device-less site for islet and cellular transplantation

Blood pressure during long-term cilostazol-based dual antiplatelet therapy after stroke: a post hoc analysis of the CSPS.com trial

Clarifying social norms which have robustness against reputation costs and defector invasion in indirect reciprocity

Information aggregation and collective intelligence beyond the wisdom of crowds

CD82 is a marker to isolate β cell precursors from human iPS cells and plays a role for the maturation of β cells

Majority rule can help solve difficult tasks even when confident members opt out to serve individual interests

Single-cell analyses of human islet cells reveal de-differentiation signatures

Cell encapsulation enhances antidepressant effect of the mesenchymal stem cells and counteracts depressive-like behavior of treatment-resistant depressed rats

Cervical spinal cord stimulation exerts anti-epileptic effects in a rat model of epileptic seizure through the suppression of CCL2-mediated cascades

Influence of hospital capabilities and prehospital time on outcomes of thrombectomy for stroke in Japan from 2013 to 2016

Silencing the G-protein coupled receptor 3-salt inducible kinase 2 pathway promotes human β cell proliferation

Ferroptosis-inducing agents compromise in vitro human islet viability and function

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