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Showing 1–5 of 5 results
Advanced filters: Author: Tatyana Bodrug Clear advanced filters

  • The cell cycle regulatory E3 ligase APC/C cooperates with UBE2C to prime substrates with ubiquitin and UBE2S to extend the ubiquitin chains. Careful analysis reveals that binding of the UBE2S to APC/C accelerates the rate-limiting step of APC/C–UBE2C.

    • Raquel C. Martinez-Chacin
    • Tatyana Bodrug
    • Nicholas G. Brown
    Research
    Nature Structural & Molecular Biology
    Volume: 27, P: 550-560

  • The APC/C ubiquitylates histones to regulate gene expression in pluripotent cells. Here, the authors pair cryo-EM and biochemical and biophysical assays to show that instead of modifying nucleosome-incorporated histones, the APC/C ubiquitylates extranucleosomal histone complexes through a mechanism that bypasses canonical substrate degrons.

    • Aleksandra Skrajna
    • Tatyana Bodrug
    • Robert K. McGinty
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-16

  • Mass photometry is a label-free optical approach capable of detecting, imaging and accurately measuring the mass of single biomolecules in solution. Here, the authors demonstrate the potential of mass photometry for quantitatively characterizing sample heterogeneity of purified protein complexes with implications for structural studies specifically and in vitro studies more generally.

    • Adar Sonn-Segev
    • Katarina Belacic
    • Philipp Kukura
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-10

  • Here, using cryogenic electron microscopy and cryoDRGN, the authors delineate how the anaphase-promoting complex/cyclosome is reconfigurated to interact with its cognate E2s and thus polyubiquitinate its target. Unexpectedly, multiple ubiquitin moieties are shown to interact with the anaphase-promoting complex/cyclosome machinery, including its activator Cdh1.

    • Tatyana Bodrug
    • Kaeli A. Welsh
    • Nicholas G. Brown
    ResearchOpen Access
    Nature Structural & Molecular Biology
    Volume: 30, P: 1663-1674

  • A small-molecule ligand of the APC/C activator Cdc20, which prolongs mitosis in unperturbed cells, instead shortens mitosis when the spindle checkpoint is activated, producing an opposite effect in a different regulatory context.

    • Katherine V. Richeson
    • Tatyana Bodrug
    • Randall W. King
    Research
    Nature Chemical Biology
    Volume: 16, P: 546-555