Nature Search

Rahman et al. reply

Taufiq Rahman
Alexander Skupin
Colin W. Taylor
Research12 Oct 2011
Nature

Volume: 478, P: E2-E3
Clustering of InsP₃ receptors by InsP₃ retunes their regulation by InsP₃ and Ca²⁺

This papers shows that inositol-1,4,5-trisphosphate (InsP₃) receptors aggregate in responses to InsP₃, resulting in a lower probability of channel opening, and that increases in intracellular Ca²⁺ can effectively relieve this inhibition and enhance the coupling between receptors in a cluster. This mechanism probably serves to enhance the sensitivity to changes in intracellular Ca²⁺.

Taufiq-Ur-Rahman
Alexander Skupin
Colin W. Taylor
Research25 Feb 2009
Nature

Volume: 458, P: 655-659
Segregated cation flux by TPC2 biases Ca²⁺ signaling through lysosomes

TPC2 is a lysosomal ion channel permeable to both calcium and sodium ions. Here, the authors show that TPC2 can selectively increase its calcium permeability when simultaneously challenged by both its natural activators- NAADP and PI(3,5)P₂.

Yu Yuan
Dawid Jaślan
Sandip Patel
ResearchOpen Access02 Aug 2022
Nature Communications

Volume: 13, P: 1-13
Systematical study of multi-walled carbon nanotube nanofluids based disposed transformer oil

Nur Sabrina Suhaimi
Muhamad Faiz Md Din
Jianli Wang
ResearchOpen Access02 Dec 2020
Scientific Reports

Volume: 10, P: 1-8
A plastid two-pore channel essential for inter-organelle communication and growth of Toxoplasma gondii

Two-pore channels (TPCs) are cation channels that localize to acidic organelles to regulate Ca²⁺ dependent events. Here, Li et al. characterize a TPC from Toxoplasma gondii(TgTPC) that localizes to the apicoplast, is critical for maintaining its integrity and relevant for Ca²⁺ uptake from the ER through stabilizing inter-organelle contact.

Zhu-Hong Li
Thayer P. King
Silvia N. J. Moreno
ResearchOpen Access04 Oct 2021
Nature Communications

Volume: 12, P: 1-14
Synthetic partial agonists reveal key steps in IP₃ receptor activation

H/D exchange reactions in the high vacuum of a mass spectrometer reveal how crown ethers move between ammonium ion binding sites of an oligolysine peptide. This study enables the dynamics of non-covalent interactions to be probed in a unique environment and could be applied to more complex artificial or natural systems.

Ana M Rossi
Andrew M Riley
Colin W Taylor
Research09 Aug 2009
Nature Chemical Biology

Volume: 5, P: 631-639
Author Correction: Structure based functional identification of an uncharacterized protein from Coxiella burnetii involved in adipogenesis

Tajul Islam Mamun
Mohammed Bourhia
Baye Sitotaw
Amendments and CorrectionsOpen Access10 Sept 2024
Scientific Reports

Volume: 14, P: 1
An online cursive handwritten medical words recognition system for busy doctors in developing countries for ensuring efficient healthcare service delivery

Shaira Tabassum
Nuren Abedin
Ashir Ahmed
ResearchOpen Access04 Mar 2022
Scientific Reports

Volume: 12, P: 1-13
Unveiling some FDA-approved drugs as inhibitors of the store-operated Ca²⁺ entry pathway

Saifur Rahman
Taufiq Rahman
ResearchOpen Access16 Oct 2017
Scientific Reports

Volume: 7, P: 1-13
Structure based functional identification of an uncharacterized protein from Coxiella burnetii involved in adipogenesis

Tajul Islam Mamun
Mohammed Bourhia
Baye Sitotaw
ResearchOpen Access22 Jul 2024
Scientific Reports

Volume: 14, P: 1-15
Human soluble CD39 displays substrate inhibition in a substrate-specific manner

Venkat M. K. Vadlamani
Kavinda K. J. Gunasinghe
Matthew T. Harper
ResearchOpen Access02 Jun 2023
Scientific Reports

Volume: 13, P: 1-12
Prognostic implications of troponin T variations in inherited cardiomyopathies using systems biology

Rameen Shakur
Juan Pablo Ochoa
Lorenzo Monserrat
ResearchOpen Access14 Jun 2021
npj Genomic Medicine

Volume: 6, P: 1-11
Exploration of inositol 1,4,5-trisphosphate (IP₃) regulated dynamics of N-terminal domain of IP₃ receptor reveals early phase molecular events during receptor activation

Aneesh Chandran
Xavier Chee
Taufiq Rahman
ResearchOpen Access21 Feb 2019
Scientific Reports

Volume: 9, P: 1-13
Inhibition of indole production increases the activity of quinolone antibiotics against E. coli persisters

Ashraf Zarkan
Marta Matuszewska
David K. Summers
ResearchOpen Access16 Jul 2020
Scientific Reports

Volume: 10, P: 1-10
Discovery of a small-molecule binder of the oncoprotein gankyrin that modulates gankyrin activity in the cell

Anasuya Chattopadhyay
Cornelius J. O’Connor
Laura S. Itzhaki
ResearchOpen Access05 Apr 2016
Scientific Reports

Volume: 6, P: 1-11
Isolated pores dissected from human two-pore channel 2 are functional

Christopher J. Penny
Taufiq Rahman
Sandip Patel
ResearchOpen Access12 Dec 2016
Scientific Reports

Volume: 6, P: 1-11

Search

Rahman et al. reply

Clustering of InsP₃ receptors by InsP₃ retunes their regulation by InsP₃ and Ca²⁺

Segregated cation flux by TPC2 biases Ca²⁺ signaling through lysosomes

Systematical study of multi-walled carbon nanotube nanofluids based disposed transformer oil

A plastid two-pore channel essential for inter-organelle communication and growth of Toxoplasma gondii

Synthetic partial agonists reveal key steps in IP₃ receptor activation

Author Correction: Structure based functional identification of an uncharacterized protein from Coxiella burnetii involved in adipogenesis

An online cursive handwritten medical words recognition system for busy doctors in developing countries for ensuring efficient healthcare service delivery

Unveiling some FDA-approved drugs as inhibitors of the store-operated Ca²⁺ entry pathway

Structure based functional identification of an uncharacterized protein from Coxiella burnetii involved in adipogenesis

Human soluble CD39 displays substrate inhibition in a substrate-specific manner

Prognostic implications of troponin T variations in inherited cardiomyopathies using systems biology

Exploration of inositol 1,4,5-trisphosphate (IP₃) regulated dynamics of N-terminal domain of IP₃ receptor reveals early phase molecular events during receptor activation

Inhibition of indole production increases the activity of quinolone antibiotics against E. coli persisters

Discovery of a small-molecule binder of the oncoprotein gankyrin that modulates gankyrin activity in the cell

Isolated pores dissected from human two-pore channel 2 are functional

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