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Showing 1–2 of 2 results
Advanced filters: Author: Te-Yu Kao Clear advanced filters

  • AlphaFold2 default prediction pipeline assigns predominantly a single conformation for a given input sequence. Here, authors developed DEERFold, which incorporates experimental Double Electron Electron (DEER) distance distributions into the AlphaFold2 network to successfully guide AlphaFold2 to sample multiple conformations.

    • Tianqi Wu
    • Richard A. Stein
    • Hassane S. Mchaourab
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-17

  • Lan et al. make single and triple phosphomimetic mutations in a long flexible loop domain of BCL-2 and show that these mutations reduce structural flexibility and promote ligand access to the groove. Their study indicates that changes in structural flexibility on an unstructured loop can activate an allosteric, otherwise inactive protein.

    • Yu-Jing Lan
    • Pei-Shan Yeh
    • Yun-Wei Chiang
    ResearchOpen Access
    Communications Biology
    Volume: 3, P: 1-10