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Showing 1–2 of 2 results
Advanced filters: Author: Tea Carletti Clear advanced filters

  • Innate immune responses are essential in the control of flavivirus infection. Here, the authors provide evidence that the unfolded protein response and the pattern recognition receptor pathways synergize to orchestrate innate antiviral responses and cell intrinsic inhibition of viral replication, a process mediated by IRF3.

    • Tea Carletti
    • Mohammad Khalid Zakaria
    • Alessandro Marcello
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-9

  • Gioia, Tavella et al. show that severe acute respiratory syndrome coronavirus 2 causes DNA damage through CHK1 degradation and impairs 53BP1 recruitment to DNA lesions. The induced DNA damage is associated with expression of pro-inflammatory cytokines and senescence markers.

    • Ubaldo Gioia
    • Sara Tavella
    • Fabrizio d’Adda di Fagagna
    ResearchOpen Access
    Nature Cell Biology
    Volume: 25, P: 550-564