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Showing 1–3 of 3 results
Advanced filters: Author: Ted H. Haley Clear advanced filters

  • Nerve injury activates microglia to remove spinal synapses, disrupting spinal sensory processing and contributing to chronic pain. Blocking complement protein C1q preserves synapses, highlighting a potential therapeutic target for neuropathic pain.

    • Noosha Yousefpour
    • Shannon N. Tansley
    • Alfredo Ribeiro-da-Silva
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-16

  • Useful materials must satisfy multiple objectives. The Pareto front expresses the trade-offs of competing objectives. This work uses a self-driving laboratory to map out the Pareto front for making highly conductive coatings at low temperatures.

    • Benjamin P. MacLeod
    • Fraser G. L. Parlane
    • Curtis P. Berlinguette
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-10

  • KDM5 histone demethylases promote the survival of drug-tolerant persister (DTP) cells in certain cancers. CPI-455, a chemical probe specific for KDM5, elevates cellular H3K4 methylation levels and reduces DTP cell numbers, suggesting that KDM5 is a viable target for cancer combination treatment.

    • Maia Vinogradova
    • Victor S Gehling
    • Marie Classon
    Research
    Nature Chemical Biology
    Volume: 12, P: 531-538