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Showing 1–5 of 5 results
Advanced filters: Author: Teddy Jégu Clear advanced filters

  • Maria V Gomez Roldan, Farhaj Izhaq et al. study the role of WIP transcription factors in Arabidopsis thaliana. Using an inducible system, they generate ChIP-seq and RNA-seq data that reveal how WIP proteins repress development and growth. Through ectopic expression of WIP in Arabidopsis carpels, they obtain male flower, mimicking sex determination in melon.

    • Maria Victoria Gomez Roldan
    • Farhaj Izhaq
    • Abdelhafid Bendahmane
    ResearchOpen Access
    Communications Biology
    Volume: 3, P: 1-12

  • The mammalian inactive X-chromosome (Xi) is organized into megadomains and superloops directed by the noncoding loci, Dxz4 and Firre. Here the authors provide evidence that megadomains do not precede Xist expression or Xi gene silencing, and suggest that Dxz4, Firre, and megadomains are dispensable for Xi silencing and escape from X-inactivation.

    • John E. Froberg
    • Stefan F. Pinter
    • Jeannie T. Lee
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-19

  • Three-dimensional genome organization can shape gene expression by facilitating interactions between regulatory elements. The authors review the process of X-chromosome inactivation with a focus on chromatin organization and subnuclear localization of the active and inactive X chromosomes, as well as the potential roles of long non-coding RNAs.

    • Teddy Jégu
    • Eric Aeby
    • Jeannie T. Lee
    Reviews
    Nature Reviews Genetics
    Volume: 18, P: 377-389