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The oncolytic adenovirus TILT-123 with pembrolizumab in platinum resistant or refractory ovarian cancer: the phase 1a PROTA trial

TILT-123 is an oncolytic adenovirus encoding TNFα and IL-2. Here the authors report the results of a phase 1a trial of TILT-123 combined with anti-PD1 pembrolizumab in patients with platinum resistant or refractory ovarian cancer.

Matthew Stephen Block
James Hugo Armstrong Clubb
Akseli Hemminki
ResearchOpen Access05 Feb 2025
Nature Communications

Volume: 16, P: 1-14
Molecular profiling of ex vivo prostate cancer CAF models captures stromal heterogeneity and drug vulnerabilities

Frida Rantanen
Astrid Murumägi
Olli Kallioniemi
ResearchOpen Access06 Nov 2025
Cell Death Discovery

Volume: 11, P: 1-10
SHARPIN is an endogenous inhibitor of β1-integrin activation

Ivaska and colleagues identify SHARPIN as an inhibitor of integrin activity in an RNAi screen for integrin regulators. They show that SHARPIN acts by binding to the cytoplasmic domain of integrin α-subunits and reduces the recruitment of talin and kindlin to the β-subunits.

Juha K. Rantala
Jeroen Pouwels
Johanna Ivaska
Research25 Sept 2011
Nature Cell Biology

Volume: 13, P: 1315-1324
Prognostic implications of tumor-infiltrating T cells in early-stage endometrial cancer

Marta Mendiola
Teijo Pellinen
Andres Redondo
Research12 Oct 2021
Modern Pathology

Volume: 35, P: 256-265
Systems pathology by multiplexed immunohistochemistry and whole-slide digital image analysis

Sami Blom
Lassi Paavolainen
Teijo Pellinen
ResearchOpen Access14 Nov 2017
Scientific Reports

Volume: 7, P: 1-13
ITGB1-dependent upregulation of Caveolin-1 switches TGFβ signalling from tumour-suppressive to oncogenic in prostate cancer

Teijo Pellinen
Sami Blom
Miguel A. del Pozo
ResearchOpen Access05 Feb 2018
Scientific Reports

Volume: 8, P: 1-14
Negative regulation of EGFR signalling through integrin-α₁β₁-mediated activation of protein tyrosine phosphatase TCPTP

Elina Mattila
Teijo Pellinen
Johanna Ivaska
Research12 Dec 2004
Nature Cell Biology

Volume: 7, P: 78-85
Distinct molecular profiles and shared drug vulnerabilities in pancreatic metastases of renal cell carcinoma

Functional precision medicine approach reveals genomic and transcriptomic aberrations that distinguish pancreatic metastases from other types of ccRCC metastases and suggest potential therapeutic targets at the individual level.

Matilda Roos-Mattila
Pauliina Kallio
Hanna E. Seppänen
ResearchOpen Access20 Oct 2024
Communications Biology

Volume: 7, P: 1-18
ROR1-STAT3 signaling contributes to ovarian cancer intra-tumor heterogeneity

Emilia Piki
Alice Dini
Daniela Ungureanu
ResearchOpen Access03 Jul 2023
Cell Death Discovery

Volume: 9, P: 1-10
Drug response profiles in patient-derived cancer cells across histological subtypes of ovarian cancer: real-time therapy tailoring for a patient with low-grade serous carcinoma

Astrid Murumägi
Daniela Ungureanu
Olli Kallioniemi
ResearchOpen Access07 Dec 2022
British Journal of Cancer

Volume: 128, P: 678-690
Spatial immunoprofiling of the intratumoral and peritumoral tissue of renal cell carcinoma patients

Oscar Brück
Moon Hee Lee
Anna Kreutzman
ResearchOpen Access02 Jul 2021
Modern Pathology

Volume: 34, P: 2229-2241
Immune cell constitution in bone marrow microenvironment predicts outcome in adult ALL

Helena Hohtari
Oscar Brück
Satu Mustjoki
ResearchOpen Access11 Jan 2019
Leukemia

Volume: 33, P: 1570-1582
Immune cell contexture in the bone marrow tumor microenvironment impacts therapy response in CML

Oscar Brück
Sami Blom
Satu Mustjoki
ResearchOpen Access20 Jun 2018
Leukemia

Volume: 32, P: 1643-1656
Digital image analysis of multiplex fluorescence IHC in colorectal cancer recognizes the prognostic value of CDX2 and its negative correlation with SOX2

Digital image analysis (DIA) of multiplex fluorescence-based immunohistochemistry and visual chromogenic evaluation of CDX2, SOX2, SOX9, E-cadherin, and β-catenin in colorectal cancer are comparable, recognizing prognostic value of CDX2 and negative correlation with SOX2. Membrane staining is best evaluated visually, while DIA enables single-cell coexpression analysis and improves visualization and detection of clinicopathological and biological associations.

Nair Lopes
Christian Holst Bergsland
Jarle Bruun
ResearchOpen Access22 Oct 2019
Laboratory Investigation

Volume: 100, P: 120-134

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