The authors show that the cell-penetrating peptide DG9 enhances PMO delivery to skeletal and cardiac muscles via multiple endocytic pathways. DG9-PMO significantly boosts dystrophin restoration and cardioprotection, addressing a key challenge in the therapy of Duchenne muscular dystrophy.
- Md Nur Ahad Shah
- Harry Wilton-Clark
- Toshifumi Yokota
