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Advanced filters: Author: Tere M. Williams Clear advanced filters

  • Regulatory T (Treg) cells are developed in the thymus, and are essential for suppressing detrimental autoimmunity. Here the authors show, using mice with dampened interleukin 2 (IL-2) signaling, that IL-2 helps position the pioneer factor SATB1 to control genome-wide chromatin accessibility to facilitate Treg cell lineage commitment in the thymus.

    • Laurent Chorro
    • Masako Suzuki
    • Grégoire Lauvau
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-17