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Showing 1–2 of 2 results
Advanced filters: Author: Tessa C. Fitch Clear advanced filters

  • Inhibiting alpha-synuclein self-assembly into amyloid structures, associated with Parkinson’s disease, is a potential therapeutic intervention. Here, the authors identify the domains/sequences that are essential for alpha-synuclein aggregation and test the activity of foldamer-based antagonists to identify potential therapeutic targets.

    • Jemil Ahmed
    • Tessa C. Fitch
    • Sunil Kumar
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-17

  • The aggregation of the neuronal protein α-Synuclein is associated with the onset of Parkinson’s disease. Here the authors report a two-dimensional Fragment Assisted Structure-based technique to find antagonists of α-Synuclein aggregation and show its promise for identifying lead therapeutics for Parkinson’s disease.

    • Nicholas H. Stillman
    • Johnson A. Joseph
    • Sunil Kumar
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-25