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Showing 1–3 of 3 results

Advanced filters: Author: Thaddäus Strzalkowski Clear advanced filters

Ablation of prostaglandin E₂ signalling through dual receptor knockout in CAR T cells enhances therapeutic efficacy in solid tumours

Targeted ablation of prostaglandin E₂ (PGE₂) signalling in CAR T cells enhances their activity in PGE₂-rich solid tumours, with demonstrations of efficacy in vitro, in mouse xenografts and in patient-derived organotypic tumour spheroids.

Janina Dörr
Lisa Gregor
Sebastian Kobold
ResearchOpen Access11 Feb 2026
Nature Biomedical Engineering

P: 1-14
Single-cell transcriptomic atlas-guided development of CAR-T cells for the treatment of acute myeloid leukemia

A single-cell screening approach identifies targets for CAR-T cells in acute myeloid leukemia.

Adrian Gottschlich
Moritz Thomas
Sebastian Kobold
Research13 Mar 2023
Nature Biotechnology

Volume: 41, P: 1618-1632
Rational design of PD-1-CD28 immunostimulatory fusion proteins for CAR T cell therapy

Theo Lorenzini
Bruno L. Cadilha
Sebastian Kobold
ResearchOpen Access04 Jul 2023
British Journal of Cancer

Volume: 129, P: 696-705