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Showing 1–3 of 3 results
Advanced filters: Author: Theodore Garland Jr. Clear advanced filters

  • Multi-ancestry meta-analyses of genome-wide association studies for self-reported physical activity during leisure time, leisure screen time, sedentary commuting and sedentary behavior at work identify 99 loci associated with at least one of these traits.

    • Zhe Wang
    • Andrew Emmerich
    • Marcel den Hoed
    ResearchOpen Access
    Nature Genetics
    Volume: 54, P: 1332-1344

  • AgRP neurons in the hypothalamic arcuate nucleus (ARH) are involved in regulating hunger and energy balance. Here the authors show that knockout of the DNA methyltransferase Dnmt3a in AgRP neurons of the ARH leads to a reduction in voluntary exercise along with numerous epigenetic and gene expression changes in ARH neurons.

    • Harry MacKay
    • C. Anthony Scott
    • Robert A. Waterland
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-11

  • The energy homeostasis system maintains stability of body fat stores over time but can be overridden by activation of feeding neurocircuits during emergent or stressful conditions. In this Review, Schwartz and colleagues highlight crosstalk between homeostatic and emergency feeding circuits in the regulation of energy balance.

    • Gregory J. Morton
    • Thomas H. Meek
    • Michael W. Schwartz
    Reviews
    Nature Reviews Neuroscience
    Volume: 15, P: 367-378