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Showing 1–3 of 3 results
Advanced filters: Author: Theodore T. Drashansky Clear advanced filters

  • Regulatory T (Treg) cells are important modulators of the tumor microenvironment. Here the authors perform transcriptome profiling of immune cells from patients with renal clear cell carcinoma to find a Treg signature that correlates with poorer prognosis, with CD177 being implicated as the main mediator for related alterations in Treg activity and tumor outcome.

    • Myung-Chul Kim
    • Nicholas Borcherding
    • Weizhou Zhang
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-13

  • Ubiquitination may control protein stability or function. Here the authors show that an ubiquitination enzyme, Hectd3, ubiquitinates Stat3 and Malt1 to modulate their function but not degradation in T cells, and thereby promoting the differentiation of pathogenic Th17 cells and susceptibility to a mouse model of multiple sclerosis.

    • Jonathan J. Cho
    • Zhiwei Xu
    • Dorina Avram
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-18