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Showing 1–9 of 9 results
Advanced filters: Author: Theresa Alenghat Clear advanced filters

  • Phytate metabolism and production of inositol trisphosphate by commensal bacteria activates epithelial histone deacetylase 3 and promotes intestinal repair.

    • Shu-en Wu
    • Seika Hashimoto-Hill
    • Theresa Alenghat
    Research
    Nature
    Volume: 586, P: 108-112

  • This paper shows that specific genetic disruption of the Ncor–HdaC3 interaction in mice causes aberrant regulation of clock genes and results in abnormal circadian behaviour. These mice are also leaner and more insulin sensitive due to increased energy expenditure. Loss of a functional Ncor–HdaC3 complex in vivo changes the oscillatory patterns of several metabolic genes, demonstrating that circadian regulation of metabolism is critical for normal energy balance.

    • Theresa Alenghat
    • Katherine Meyers
    • Mitchell A. Lazar
    Research
    Nature
    Volume: 456, P: 997-1000

  • Much of the research on lung immunology has concentrated on classic hematopoietically derived cells of the immune system. In this Focus Review, Alenghat and Whitsett discuss the key innate immunological functions of the respiratory epithelium.

    • Jeffrey A Whitsett
    • Theresa Alenghat
    Reviews
    Nature Immunology
    Volume: 16, P: 27-35

  • This work identifies a role for intestinal epithelial cell (IEC)-intrinsic expression of histone deacetylase 3 in regulating commensal-bacteria-dependent gene expression and intestinal homeostasis; IEC-specific HDAC3 deficiency gives rise to Paneth cell abnormalities, impaired intestinal barrier function, and increased DSS-induced intestinal inflammation in commensal-bacteria-containing, but not germ-free, mice.

    • Theresa Alenghat
    • Lisa C. Osborne
    • David Artis
    Research
    Nature
    Volume: 504, P: 153-157

  • Artificial intelligence (AI) is a powerful tool that could be applied to microbiome research. This Perspective discusses best practices and current limitations with the application of AI in microbiome data research, giving insights into future use and practical advice and recommendations on its use.

    • Alberto Caminero
    • Carolina Tropini
    • Elena F. Verdu
    Reviews
    Nature Reviews Gastroenterology & Hepatology
    Volume: 22, P: 788-803