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Showing 1–2 of 2 results
Advanced filters: Author: Thergiory Irrazabal Clear advanced filters

  • It is unclear how microbial-induced inflammation promotes neoplastic transformation in colitis-associated cancer (CAC). Here, the authors use models of CAC to show that inflammation induces 8-oxoguanine lesions in DNA, and that antioxidants can reduce these DNA lesions as well as CAC.

    • Thergiory Irrazabal
    • Bhupesh K. Thakur
    • Alberto Martin
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-14

  • Class switch recombination (CSR) requires break and repair of immunoglobulin DNA. Here the authors show that the histone deubiquitinase Usp22 is involved in V(D)J recombination and CSR of IgG and IgE, but not IgA, and that IgG CSR is dependent on the canonical c-NHEJ pathway, whereas IgA CSR is more dependent on the alternative A-EJ pathway.

    • Conglei Li
    • Thergiory Irrazabal
    • Alberto Martin
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-12