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Showing 1–2 of 2 results
Advanced filters: Author: Therwa Hamza Clear advanced filters

  • X-ray crystal structures of the full-length TcdB exotoxin of bacterial pathogen Clostridium difficile reveal pH-dependent conformational changes that allow translocation of the toxin from endosomes into the cytosol.

    • Peng Chen
    • Kwok-ho Lam
    • Rongsheng Jin
    Research
    Nature Structural & Molecular Biology
    Volume: 26, P: 712-719

  • Clostridium difficile causes diarrhea and colitis by producing up to three different protein toxins. Here, Tam et al. show that an anthelmintic drug, niclosamide, inhibits the pathogenesis of all three toxins by targeting a host process required for toxin entry into host cells, without disrupting the gut microbiota.

    • John Tam
    • Therwa Hamza
    • Roman A. Melnyk
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-11