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ClC-1 Inhibition as a Mechanism for Accelerating Skeletal Muscle Recovery After Neuromuscular Block in Rats

Reversal agents are intravenous drugs used to accelerate recovery from neuromuscular block post-surgery. We report that inhibition of ClC-1, a skeletal muscle chloride channel, reverses any nondepolarizing blocking agent, providing a novel reversal (antagonism) mechanism.

Marianne Skals
Martin Broch-Lips
Thomas Holm Pedersen
ResearchOpen Access28 Oct 2024
Nature Communications

Volume: 15, P: 1-10
Distinct NF-κB/Rel transcription factors are responsible for tissue-specific and inducible gene activation

Thomas Lernbecher
Urs Müller
Thomas Wirth
Research21 Oct 1993
Nature

Volume: 365, P: 767-770
Stem cell-associated heterogeneity in Glioblastoma results from intrinsic tumor plasticity shaped by the microenvironment

Cancer stem cells (CSCs) comprise a putative population that can drive growth and resistance. Here, in glioblastoma models the authors show that rather than being a distinct clonal entity, the CSC population represents a plastic state adoptable by most cancer cells via reversible state transitions induced by the microenvironment.

Anne Dirkse
Anna Golebiewska
Simone P. Niclou
ResearchOpen Access16 Apr 2019
Nature Communications

Volume: 10, P: 1-16

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