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Showing 1–3 of 3 results
Advanced filters: Author: Thomas Bukur Clear advanced filters

  • Cancer is often associated with mutant transcription factors (TFs) but their functional characterization is challenging. Here, the authors describe a recurrent mutation within TF IRF4 in human lymphomas and they show how it causes a complex switch in TF specificity and functionality.

    • Nikolai Schleussner
    • Pierre Cauchy
    • Stephan Mathas
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-18

  • In this phase 1 trial, patients with locally advanced or metastatic solid tumors were treated with the individualized mRNA neoantigen-specific immunotherapy (iNeST) autogene cevumeran alone or in combination with the anti-PD-L1 agent atezolizumab, showing long-lasting neoantigen-specific immune responses and preliminary clinical activity, supporting further development of this therapeutic approach.

    • Juanita Lopez
    • Thomas Powles
    • D. Ross Camidge
    ResearchOpen Access
    Nature Medicine
    Volume: 31, P: 152-164