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Showing 1–16 of 16 results
Advanced filters: Author: Thomas E. Scammell Clear advanced filters

  • The fragmentation of sleep in Apoe−/− mice induces monocytosis and accelerated atherosclerosis due to a reduction in hypocretin that otherwise restricts bone marrow CSF1 availability.

    • Cameron S. McAlpine
    • Máté G. Kiss
    • Filip K. Swirski
    Research
    Nature
    Volume: 566, P: 383-387

  • The wake-active orexin system plays a central role in the dynamic regulation of glucose homeostasis. Here the authors report that inactivation of the orexin receptor type 1 or 2 in serotonergic neurons differentially regulate systemic glucose homeostasis in the context of diet induced obesity.

    • Xing Xiao
    • Gagik Yeghiazaryan
    • A. Christine Hausen
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-20

  • Sleep and wakefulness is stabilized by a population of orexin-expressing neurons. In this study, the authors demonstrate how these neurons drive arousal by silencing sleep-promoting neurons in the ventrolateral preoptic nucleus.

    • Roberto De Luca
    • Stefano Nardone
    • Elda Arrigoni
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-15

  • Narcolepsy is a sleep disorder caused by selective loss of orexin-producing neurons. Scammell and colleagues describe the functions of orexin neurons and the effects of their loss and review evidence implicating the immune system in the pathogenesis of the disorder.

    • Carrie E. Mahoney
    • Andrew Cogswell
    • Thomas E. Scammell
    Reviews
    Nature Reviews Neuroscience
    Volume: 20, P: 83-93

  • AgRP neurons of the arcuate nucleus of the hypothalamus promote homeostatic feeding yet are rapidly suppressed by food-related sensory cues. The authors identify a population of inhibitory DMH-LepR neurons that relays real-time information about the nature and availability of food to dynamically modulate ARC-AgRP neuron activity and feeding behavior.

    • Alastair S Garfield
    • Bhavik P Shah
    • Bradford B Lowell
    Research
    Nature Neuroscience
    Volume: 19, P: 1628-1635

  • Anatomical lesions of the preoptic area (POA) can cause sleep loss while electrical, chemical, or thermal stimulation of POA can induce sleep. To better understand the exact neural function of the POA, this study shows that galanin and GABA+ inhibitory neurons in the ventrolateral POA that project to the wake-promoting tuberomammillary nucleus promote sleep in a stimulation frequency dependent manner.

    • Daniel Kroeger
    • Gianna Absi
    • Ramalingam Vetrivelan
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-14

  • Orexins are known to regulate sleep and feeding, but a study in Nature now shows that they are also involved in drug-seeking behavior. This suggests a larger role for orexin-producing neurons as an interface between internal states and motivated behaviors.

    • Thomas E Scammell
    • Clifford B Saper
    News & Views
    Nature Neuroscience
    Volume: 8, P: 1286-1288

  • An orally available drug enters the brain and interferes with signaling of orexin neuropeptides—providing a potential treatment for sleep disorders and possibly addiction (pages 150–155).

    • Thomas E Scammell
    • Clifford B Saper
    News & Views
    Nature Medicine
    Volume: 13, P: 126-128

  • In the past 20 years, understanding of the clinical manifestations, aetiopathophysiology, diagnosis and treatment of narcolepsy has greatly advanced. In this Review, Bassetti et al. present these advances, discuss unmet needs and offer future perspectives for the field of narcolepsy.

    • Claudio L. A. Bassetti
    • Antoine Adamantidis
    • Yves Dauvilliers
    Reviews
    Nature Reviews Neurology
    Volume: 15, P: 519-539

  • Acute exposure to a variety of pathogens or inflammatory insults leads to a well-characterized set of responses in the CNS, aimed at promoting the clearance of the infecting agent. In this review, the authors examine the various symptoms of this 'sickness syndrome' and the actions of prostaglandins in linking inflammation with these CNS responses.

    • Clifford B Saper
    • Andrej A Romanovsky
    • Thomas E Scammell
    Reviews
    Nature Neuroscience
    Volume: 15, P: 1088-1095