Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–5 of 5 results
Advanced filters: Author: Thomas Fouqueau Clear advanced filters

  • Understanding the structural basis for the inhibition of archaeal eukaryotic-like RNA polymerases (RNAPs) during virus infection is of interest for drug design. Here, the authors present the cryo-EM structures of apo Sulfolobus acidocaldarius RNAP and the RNAP complex structures with two regulatory factors, RIP and TFS4 that inhibit transcription and discuss their inhibitory mechanisms.

    • Simona Pilotto
    • Thomas Fouqueau
    • Finn Werner
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-15

  • CRISPR arrays form the physical memory of prokaryotic adaptive immune systems by incorporating viral DNA sequences as spacers. Here, Blombach et al. show that transcription factor Cbp1 recruits chromatin protein Cren7 at CRISPR arrays, forming ‘chimeric’ chromatin-like structures that regulate expression of long CRISPR arrays in Sulfolobales archaea.

    • Fabian Blombach
    • Michal Sýkora
    • Finn Werner
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-17

  • Transcription in archaea is known to be regulated through the recruitment of RNA polymerase to promoters. Here, the authors show that the archaeon Saccharolobus solfataricus regulates transcription globally through a rate-limiting promoter-proximal elongation step.

    • Fabian Blombach
    • Thomas Fouqueau
    • Finn Werner
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-15

  • Transcript cleavage factors such as eukaryotic TFIIS assist the resumption of transcription following RNA pol II backtracking. Here the authors find that one of the Sulfolobus solfataricus TFIIS homolog—TFS4—has evolved into a potent RNA polymerase inhibitor potentially involved in antiviral defense.

    • Thomas Fouqueau
    • Fabian Blombach
    • Finn Werner
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-13

  • Functional in vitro assays, a 1.9 Å X-ray structure and AlphaFold2 homology models reveal how the archaeal histone variant MJ1647 from Methanocaldococcus jannaschi forms a tetrameric complex capable of DNA bridging.

    • Sapir Ofer
    • Fabian Blombach
    • Finn Werner
    ResearchOpen Access
    Communications Biology
    Volume: 6, P: 1-16