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Showing 1–9 of 9 results
Advanced filters: Author: Thomas J. Maimone Clear advanced filters

  • The natural product nimbolide covalently reacts with a functional cysteine of the E3 ubiquitin ligase RNF114, resulting in impaired substrate recognition and degradation, enabling the use of nimbolide for targeted protein degradation.

    • Jessica N. Spradlin
    • Xirui Hu
    • Daniel K. Nomura
    Research
    Nature Chemical Biology
    Volume: 15, P: 747-755

  • Members of the hapalindole, fischerindole, welwitindolinone and ambiguine families were synthesized, each constructed without the use of a single protecting group. As a consequence, molecules that have previously required 20 or more steps to synthesize racemically in milligram amounts can now be procured as single enantiomers in significant quantities in 10 steps or less.

    • Phil S. Baran
    • Thomas J. Maimone
    • Jeremy M. Richter
    Research
    Nature
    Volume: 446, P: 404-408

  • Manumycin natural products were found to target the E3 ligase UBR7 and engage in molecular glue interactions with p53, leading to the activation of p53 and cell death.

    • Yosuke Isobe
    • Mikiko Okumura
    • Daniel K. Nomura
    Research
    Nature Chemical Biology
    Volume: 16, P: 1189-1198

  • Meroterpenes are a particularly important class of biologically active bicyclo[3.3.1]nonane-containing molecules. Here, the authors report a general strategy toward these valuable targets based on abiotic annulation/rearrangement steps resulting in a concise total synthesis of garsubellin A.

    • Xingyu Shen
    • Chi P. Ting
    • Thomas J. Maimone
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-8

  • Mimicking biosynthetic pathways can provide access to medicinally important natural products, but generating the reactive species used by nature can often be difficult. Now, a photoredox-based strategy has been developed to access a reactive radical intermediate postulated to be involved in complex lignan biosynthesis.

    • Danny Q. Thach
    • Thomas J. Maimone
    News & Views
    Nature Chemistry
    Volume: 13, P: 7-9

  • Iodine atoms can be fitted with a chemical jacket to control the conversion of simple carbon chains into complex iodine-containing molecules. Previously, such reactions were only possible with enzymes.

    • Phil S. Baran
    • Thomas J. Maimone
    News & Views
    Nature
    Volume: 445, P: 826-827

  • A synthetic lethal CRISPR–Cas9 screen identifies ferroptosis suppressor protein 1 as a key ferroptosis-resistance factor, the expression of which correlates with ferroptosis resistance in hundreds of cancer cell lines.

    • Kirill Bersuker
    • Joseph M. Hendricks
    • James A. Olzmann
    Research
    Nature
    Volume: 575, P: 688-692