The differentiation of naïve T helper cells into effector subsets is a critical step in the adaptive immune response to pathogens. Here the authors identify a large number of lncRNAs in activated human lymphocytes and identify a Th2 lineage-specific lncRNA cluster that regulates the expression of genes encoding Th2 cytokines.
- Charles F. Spurlock III
- John T. Tossberg
- Thomas M. Aune