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Showing 1–2 of 2 results
Advanced filters: Author: Thomas M. Leissing Clear advanced filters

  • The efficacy of carbapenem antibiotics can be compromised by metallo-β-lactamases, but a high-throughput screen followed by optimization has now enabled the discovery of indole-2-carboxylates (InCs) as potent broad-spectrum metallo-β-lactamase inhibitors. The results highlight the potential of InC–carbapenem combinations for clinical use as well as mechanism-guided approaches to combatting globally disseminated antibiotic resistant mechanisms.

    • Jürgen Brem
    • Tharindi Panduwawala
    • Christopher J. Schofield
    Research
    Nature Chemistry
    Volume: 14, P: 15-24

  • Hypoxia-inducible factor (FIH) is an oxygenase which post-translationally hydroxylates proteins and is implicated in a range of biological processes. Here a wide substrate tolerance for FIH is demonstrated, including for d-amino acids, where double hydroxylation of d-leucine is observed.

    • Hwanho Choi
    • Adam P. Hardy
    • Christopher J. Schofield
    ResearchOpen Access
    Communications Chemistry
    Volume: 3, P: 1-10