Despite the significance of high pressure in the story of life on Earth, our current understanding of biochemistry at high pressure is limited, primarily due to technological challenges associated with using pressure as an experimental variable. Here, the authors report in situ high-pressure magic-angle spinning solid-state nuclear magnetic resonance spectroscopy to study the fluidity of model microbial membranes at pressures up to 28 MPa, showing a stoichiometric effect of lipids in the membrane on the phospholipid lateral diffusion at high pressure.
- Thomas M. Osborn Popp
- Mithun Karthikeyan
- Andrew J. Nieuwkoop
