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Showing 1–7 of 7 results
Advanced filters: Author: Thomas Mandel Clausen Clear advanced filters

  • Here, the authors discover small molecules that inhibit glycosylation processes that occur in the Golgi apparatus of cells. The molecules reversibly inhibit formation of elaborate glycan structures without affecting secretion of glycoproteins.

    • Daniel Madriz Sørensen
    • Christian Büll
    • Yoshiki Narimatsu
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-19

  • Cancer cells often acquire molecular patterns of fast-growing embryonic tissues to enable propagation and invasion, which distinguish tumour tissues from their healthy adult counterpart. Here authors develop antibody fragments which specifically target oncofetal chondroitin sulphate on the cancer cell surface and in the tumour stroma, with the antibodies achieving therapeutic effect in multiple mouse models in antibody drug conjugate and bispecific immune cell engager formats.

    • Elena Ethel Vidal-Calvo
    • Anne Martin-Salazar
    • Ali Salanti
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-20

  • In placental malaria, interactions between parasite protein VAR2CSA and human glycosaminoglycan chondroitin sulfate A (CS) sequesters infected red blood cells in the placenta. Here, the authors provide cryo-EM structures of VAR2CSA and placental CS, identifying molecular interactions that could guide design of placental malaria vaccines.

    • Kaituo Wang
    • Robert Dagil
    • Ali Salanti
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-10

  • Severe COVID-19 is associated with epithelial and endothelial barrier dysfunction, however, the molecular pathways resulting in endothelial barrier dysfunction and vascular leakage are only sparsely understood. Here, Biering et al. show that SARS-CoV-2 spike protein is sufficient to induce barrier dysfunction and vascular leak. They show a role for integrins, TGF-beta, ECM remodeling enzymes, and glycosaminoglycans in this S-mediated barrier dysfunction.

    • Scott B. Biering
    • Francielle Tramontini Gomes de Sousa
    • Eva Harris
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-19

  • The anti-leprosy drug clofazimine inhibits coronavirus replication in several cell models and shows potent antiviral activity against SARS-CoV-2 infection in a hamster model, particularly when used in combination with remdesivir.

    • Shuofeng Yuan
    • Xin Yin
    • Kwok-Yung Yuen
    Research
    Nature
    Volume: 593, P: 418-423