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Showing 1–27 of 27 results
Advanced filters: Author: Thomas Manke Clear advanced filters

  • Exposure to inflammation drives hematopoietic stem cells (HSC) aging, limiting their self-renewal capacity and differentiation. Here, the authors explore the mechanistic link between inflammation and HSC aging. Using mouse models, they identify the innate immune RNA sensor MDA5 as a key mediator of HSC aging and show that MDA5 loss ameliorates the aging phenotype by improving proteostasis in aged HSCs.

    • Veronica Bergo
    • Pavlos Bousounis
    • Eirini Trompouki
    ResearchOpen Access
    Nature Communications
    Volume: 17, P: 1-22

  • Neuronal differentiation requires rearrangement of the transcriptional and chromatin landscapes of neural cells. Here, the authors study in-vitro neuronal differentiation of murine embryonic stem cells (ESCs) to show that this process is modulated by DOT1L activity, which regulates H3K79me2 accumulation, and preserves accessibility of SOX2-bound enhancers.

    • Francesco Ferrari
    • Laura Arrigoni
    • Thomas Manke
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-13

  • Zimmermann et al. present OrgaPlexing, an imaging pipeline mapping metabolic organelles and their interactions. They find changes in mitochondria, ER, peroxisome and lipid droplet dynamics that impact macrophage inflammatory lipid mediator synthesis.

    • Julia A. Zimmermann
    • Kerstin Lucht
    • Angelika S. Rambold
    ResearchOpen Access
    Nature Cell Biology
    Volume: 26, P: 1261-1273

  • After loss of MSL2, a class of dosage-sensitive genes transitions from biallelic to monoallelic expression, whereby one allele remains active, retaining active histone modifications and transcription factor binding, and the other allele is silenced, exhibiting loss of promoter–enhancer contacts and the acquisition of DNA methylation.

    • Yidan Sun
    • Meike Wiese
    • Asifa Akhtar
    ResearchOpen Access
    Nature
    Volume: 624, P: 173-181

  • Spin-polarized neutrons are sensitive to magnetic fields, and they can relatively easily penetrate through matter. A new imaging technique uses these two properties for mapping the three-dimensional distribution of magnetic fields inside massive objects.

    • Nikolay Kardjilov
    • Ingo Manke
    • John Banhart
    Research
    Nature Physics
    Volume: 4, P: 399-403

  • Although topologically associating domains (TADs) have been extensively investigated, it is not clear to what extent DNA sequence contributes to their formation. Here the authors develop software to identify high-resolution TAD boundaries and reveal their relationship to underlying DNA motifs.

    • Fidel Ramírez
    • Vivek Bhardwaj
    • Thomas Manke
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-15

  • The mechanisms that initiate heterochromatin formation and maintain its distinction from euchromatin have remained elusive. However, a new study reveals a pathway in which transcriptional repression of pericentric repeats by sequence-specific transcription factors is essential for the integrity of heterochromatin, thereby considerably expanding the role of transcription factors beyond euchromatic gene regulation.

    • Aydan Bulut-Karslioglu
    • Valentina Perrera
    • Thomas Jenuwein
    Research
    Nature Structural & Molecular Biology
    Volume: 19, P: 1023-1030

  • Zhang et al. use single-cell RNA sequencing and functional analyses to describe the hyaluronic acid–GPRC5C signalling axis as an essential component controlling the state of dormancy for human and mouse haematopoietic stem cells.

    • Yu Wei Zhang
    • Julian Mess
    • Nina Cabezas-Wallscheid
    ResearchOpen Access
    Nature Cell Biology
    Volume: 24, P: 1038-1048

  • ACKR3 is a critical regulator of platelet-mediated thrombosis and organ injury following ischemia/reperfusion. Platelet ACKR3 surface expression is independently associated with all-cause mortality in patients with cardiovascular diseases.

    • Anne-Katrin Rohlfing
    • Kyra Kolb
    • Meinrad Gawaz
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-20

  • MSL1, a component of the Drosophila dosage compensation complex, genetically and biochemically interacts with CDK7, a subunit of the TFIIH transcription factor, thus revealing a complex interplay between MSL1 and the general transcriptional machinery.

    • Sarantis Chlamydas
    • Herbert Holz
    • Asifa Akhtar
    Research
    Nature Structural & Molecular Biology
    Volume: 23, P: 580-589

  • Comprehensive characterisation of RNA-protein interactions requires different levels of resolution. Here, the authors present an integrated mass spectrometry-based approach that allows them to define the Drosophila RNA-protein interactome from the level of multisubunit complexes down to the RNA-binding amino acid.

    • Amol Panhale
    • Florian M. Richter
    • Asifa Akhtar
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-22

  • The combination of X-ray and neutron CT enables 4D studies, i.e. to explore the evolution of 3D structures with time. Here the authors apply this approach to a Li-ion primary cell, revealing elsewhere unseen trends in the spatial distribution of performance aided by a new ‘unrolling’ methodology.

    • Ralf F. Ziesche
    • Tobias Arlt
    • Paul R. Shearing
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-11

  • The position, shape and number of transcription start sites (TSS) regulate gene expression. Here authors present MAPCap, a method for high-resolution detection and differential expression analysis of TSS, and apply MAPCap to early fly development, detecting stage and sex-specific promoter and enhancer activity.

    • Vivek Bhardwaj
    • Giuseppe Semplicio
    • Asifa Akhtar
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-15

  • Characterisation of water dynamics in polymer electrolyte fuel cells is important for technology development. Here, the authors demonstrate a 4D neutron imaging technique, enabling quantitative analysis of the local water evolution, and identify performance parameters for water management.

    • Ralf F. Ziesche
    • Jennifer Hack
    • Paul R. Shearing
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-11

  • This study shows that the transcription factor SRF, expressed in neurons, crucially affects oligodendrocyte maturation and myelination through a non–cell autonomous mechanism. SRF appears to act, at least in part, by repressing transcription of the paracrine growth factor CTGF. Overexpression of CTGF reduced oligodendrocyte differentiation.

    • Christine Stritt
    • Sina Stern
    • Bernd Knöll
    Research
    Nature Neuroscience
    Volume: 12, P: 418-427

  • In most eukaryotes, the centromere is defined by epigenetic marks such as the histone H3 variant CENH3/CENP-A/CID. Ectopic induction of kinetochores in Drosophila S2 cells by CID overexpression leads to kinetochore assembly specifically in silent intergenic regions bordering heterochomratin, demonstrating a role for these domains in centromere identity.

    • Agata M. Olszak
    • Dominic van Essen
    • Patrick Heun
    Research
    Nature Cell Biology
    Volume: 13, P: 799-808

  • Here, Thomas Boehm considers the commonalities that underlie the adaptive immune systems of jawless and jawed vertebrates, including functionally distinct B- and T-like cells and anatomically segregated sites for their generation, as well somatically diversified and clonally expressed antigen receptors. The features that distinguish the adaptive immune systems in these vertebrate groups are also considered.

    • Thomas Boehm
    Reviews
    Nature Reviews Immunology
    Volume: 11, P: 307-317

  • Laura Arrigoni et al. present RELACS, a method enabling high-throughput ChIP-seq which involves barcoding and processing intact nuclei in the same ChIP reaction. The method is useful for broad cell types and epitopes, robust to experimental conditions, and drastically decreases workload.

    • Laura Arrigoni
    • Hoor Al-Hasani
    • Thomas Manke
    ResearchOpen Access
    Communications Biology
    Volume: 1, P: 1-12

  • Schnabel et al. identify and characterize piperine synthase in developing black pepper fruits which catalyses the formation of piperine from piperoyl coenzyme A and piperidine. A member of BAHD-type acyltransferases, this enzyme can be useful for bio-production of a broad range of medicinally relevant piperamides.

    • Arianne Schnabel
    • Benedikt Athmer
    • Thomas Vogt
    ResearchOpen Access
    Communications Biology
    Volume: 4, P: 1-10