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Showing 1–2 of 2 results
Advanced filters: Author: Thomas Owley Clear advanced filters

  • Autism spectrum disorders (ASDs) are neurodevelopmental disorders characterized by impairments in social and communication skills. Accumulating evidence suggests a genetic component to ASDs, and here a two-stage, genome-wide approach is used to identify candidate genomic loci enriched in ASD cases. The majority of these loci are found to be involved in neuronal adhesion and ubiquitin degradation, suggesting novel susceptibility mechanisms.

    • Joseph T. Glessner
    • Kai Wang
    • Hakon Hakonarson
    Research
    Nature
    Volume: 459, P: 569-573

  • Although structural variation has been previously associated with autism spectrum disorders, this study reports a genome-wide significant association of common variants with susceptibility to this disorder group. The results implicate neuronal cell-adhesion molecules in the pathogenesis of this group of neurodevelopmental and neuropsychiatric disorders.

    • Kai Wang
    • Haitao Zhang
    • Hakon Hakonarson
    Research
    Nature
    Volume: 459, P: 528-533