Nature Search

Deep immune profiling delineates hallmarks of disease heterogeneity in extrapulmonary tuberculosis

This work uses gene expression and single cell analyses to group extrapulmonary tuberculosis patients into three immune types, revealing immune pathways driving pathogenesis and markers that could improve diagnosis and guide tailored treatments.

Sebastian J. Theobald
Kilian Dahm
Jan Rybniker
ResearchOpen Access10 Nov 2025
Nature Communications

Volume: 16, P: 1-20
Spatially embedded growing small-world networks

Ari Zitin
Alexander Gorowara
Edward Ott
ResearchOpen Access14 Nov 2014
Scientific Reports

Volume: 4, P: 1-5
A whole-genome sequence and transcriptome perspective on HER2-positive breast cancers

Breast cancer is separated into multiple subtypes based on the expression of HER2 and hormone receptors. Here, the authors report the whole genome sequence of 64 HER2 positive tumours and show that these can be further separated into four groups with different gene expression profiles and genomic features.

Anthony Ferrari
Anne Vincent-Salomon
Gilles Thomas
ResearchOpen Access13 Jul 2016
Nature Communications

Volume: 7, P: 1-9
Cryo-electron microscopy structures of pyrene-labeled ADP-P_i- and ADP-actin filaments

For almost forty years, N-(1-pyrene) iodoacetamide has been used to label actin at C374, but the mechanisms of the fluorescence changes are still unknown due to the lack of structural information. Here authors provide cryo-EM structures of actin filaments with N-1-pyrene conjugated to cysteine 374 and either ADP or ADP-phosphate in the active site.

Steven Z. Chou
Thomas D. Pollard
ResearchOpen Access19 Nov 2020
Nature Communications

Volume: 11, P: 1-9
Transcriptomic profiling and machine learning uncover gene signatures of psoriasis endotypes and disease severity

Rider, Grantham, Smith, Watson et al. integrate multiomic data from patients with psoriasis using dimensionality reduction and machine learning techniques. This approach identifies biological relationships between genetic background, clinical features and disease severity, providing insight into disease variability across individuals.

Ashley Rider
Henry J. Grantham
Paola Di Meglio
ResearchOpen Access21 Jan 2026
Communications Medicine

Volume: 6, P: 1-21
Radiation Effects in Plant Nutrition Experiments with Phosphorus-32

C. BOULD
D. J. D. NICHOLAS
W. D. E. THOMAS
Research27 Jan 1951
Nature

Volume: 167, P: 140-142
Source of the Hydrogen Ions in Gastric Juice

EDWARD J. CONWAY
THOMAS G. BRADY
Research18 Sept 1948
Nature

Volume: 162, P: 456-457
San Miguel Sea Lion Virus Isolation, Preliminary Characterization and Relationship to Vesicular Exanthema of Swine Virus

ALVIN W. SMITH
THOMAS G. AKERS
NEYLAN A. VEDROS
Research01 Jul 1973
Nature

Volume: 244, P: 108-110
Mast cells link immune sensing to antigen-avoidance behaviour

Mast cells are shown to function as sensor cells linking antigen recognition in type 2 immunity to antigen-specific avoidance behaviour, preventing immune activation and inflammation.

Thomas Plum
Rebecca Binzberger
Hans-Reimer Rodewald
ResearchOpen Access12 Jul 2023
Nature

Volume: 620, P: 634-642
The Bifilar Pendulum at the Royal Observatory, Edinburgh

THOMAS HEATH
Research04 Jul 1895
Nature

Volume: 52, P: 223
Migration of a Water-beetle

ROSE HAIG THOMAS
Research04 Jul 1895
Nature

Volume: 52, P: 223
ZAK activation at the collided ribosome

The kinase ZAK is activated at collided ribosomes to mediate the ribotoxic stress response.

Vienna L. Huso
Shuangshuang Niu
Roland Beckmann
ResearchOpen Access19 Nov 2025
Nature

Volume: 649, P: 1051-1060
Targeted isolation of diverse human protective broadly neutralizing antibodies against SARS-like viruses

A broadly neutralizing antibody (bnAb) response is required to combat SARS-CoV-2 variants of concern (VOCs). The authors isolated and characterized a large panel of sarbecovirus bnAbs from vaccinated individuals who had recovered from COVID-19, finding that many of these antibodies were able to neutralize all VOCs, including Omicron, and demonstrate prophylaxis in mice infected with diverse sarbecoviruses.

Wan-ting He
Rami Musharrafieh
Raiees Andrabi
Research02 Jun 2022
Nature Immunology

Volume: 23, P: 960-970
Macrophages directly contribute collagen to scar formation during zebrafish heart regeneration and mouse heart repair

Macrophages mediate the fibrotic response after a heart attack by extracellular matrix turnover and cardiac fibroblasts activation. Here the authors identify an evolutionarily-conserved function of macrophages that contributes directly to the forming post-injury scar through cell-autonomous deposition of collagen.

Filipa C. Simões
Thomas J. Cahill
Paul R. Riley
ResearchOpen Access30 Jan 2020
Nature Communications

Volume: 11, P: 1-17
Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting

Hubert Schorle
Thomas Holtschke
Ivan Horak
Research15 Aug 1991
Nature

Volume: 352, P: 621-624
Nectar-Secreting Glands

THOMAS BELT
Research14 Jun 1877
Nature

Volume: 16, P: 122
Ethylation versus Methylation in Mutation of Escherichia coli and Drosophila

THOMAS ALDERSON
Research26 Sept 1964
Nature

Volume: 203, P: 1404-1405
DNA targeting by compact Cas9d and its resurrected ancestor

Ocampo et al. present several structures and the biochemical characterization of a compact Cas9 nuclease, shedding light on how these enzymes function and evolve.

Rodrigo Fregoso Ocampo
Jack P. K. Bravo
David W. Taylor
ResearchOpen Access07 Jan 2025
Nature Communications

Volume: 16, P: 1-16
The Hydractinia cell atlas reveals cellular and molecular principles of cnidarian coloniality

Here they generate a cell type atlas of the colonial cnidarian Hydractinia symbiolongicarpus, which reveals that distinct colony parts are mostly made from unique combinations of shared cell types, and identify novel cell types involved in biomineralization, and self/non-self recognition.

David A. Salamanca-Díaz
Helen R. Horkan
Jordi Solana
ResearchOpen Access03 Mar 2025
Nature Communications

Volume: 16, P: 1-20
Linking diverse salinity responses of 14 almond rootstocks with physiological, biochemical, and genetic determinants

Devinder Sandhu
Amita Kaundal
Donald L. Suarez
ResearchOpen Access03 Dec 2020
Scientific Reports

Volume: 10, P: 1-13
Distinct conformations of the HIV-1 V3 loop crown are targetable for broad neutralization

The V3-crown of the HIV-1 envelope protein largely elicits non-neutralizing antibodies. Here, the authors show that the V3-crown can be targeted by broadly neutralizing designed ankyrin repeat proteins recognizing two conformations one of which resembles CCR5- bound V3.

Nikolas Friedrich
Emanuel Stiegeler
Alexandra Trkola
ResearchOpen Access18 Nov 2021
Nature Communications

Volume: 12, P: 1-18
Vitamin K₁ Content of Maternal Milk: Influence of the Stage of Lactation, Lipid Composition, and Vitamin K₁ Supplements Given to the Mother

R v Kries
M Shearer
U Göbel
Research01 Nov 1987
Pediatric Research

Volume: 22, P: 513-517
Sequencing of prostate cancers identifies new cancer genes, routes of progression and drug targets

Joint analysis of new and previously published sequencing data for primary and metastatic prostate cancers identifies new candidate driver mutations and provides insights into disease progression and potential drug targets.

David C. Wedge
Gunes Gundem
Rosalind A. Eeles
Research16 Apr 2018
Nature Genetics

Volume: 50, P: 682-692
Structural insights into inhibitor regulation of the DNA repair protein DNA-PKcs

Cryo-electron microscopy structures of DNA-dependent protein kinase catalytic subunit bound to ATPγS and four inhibitors (wortmannin, NU7441, AZD7648 and M3814) provide molecular details and insights useful for drug design.

Shikang Liang
Sherine E. Thomas
Tom L. Blundell
ResearchOpen Access05 Jan 2022
Nature

Volume: 601, P: 643-648
An Incorrect Footnote and its Consequences

THOMAS MUIR
Research01 Mar 1888
Nature

Volume: 37, P: 438-439
Plastid-localized xanthorhodopsin increases diatom biomass and ecosystem productivity in iron-limited surface oceans

The polar diatom Fragilariopsis cylindrus can circumvent limited chlorophyll-based photosynthesis by using a rhodopsin proton pump to fuel growth.

Jan Strauss
Longji Deng
Thomas Mock
ResearchOpen Access16 Oct 2023
Nature Microbiology

Volume: 8, P: 2050-2066
Light curves and colours of the ejecta from Dimorphos after the DART impact

Optical observations of Dimorphos, a satellite of the asteroid 65803 Didymos, before, during and after the impact of the DART spacecraft, from a network of citizen science telescopes across the world are reported.

Ariel Graykowski
Ryan A. Lambert
Ian M. Transom
ResearchOpen Access01 Mar 2023
Nature

Volume: 616, P: 461-464
Acute Hyperammonemia in the Young Primate: Physiologic and Neuropathologic Correlates

Theresa M Voorhies
Michelle E Ehrlich
Fred Plum
Research01 Dec 1983
Pediatric Research

Volume: 17, P: 970-975
Alterations in Cerebral Blood Flow and Oxygen Consumption during Prolonged Hypocarbia

Nancy B Hansen
Philip T Nowicki
James A Menke
Research01 Feb 1986
Pediatric Research

Volume: 20, P: 147-150
Use of implicit motor imagery for visual shape discrimination as revealed by PET

Lawrence M. Parsons
Peter T. Fox
Jack L. Lancaster
Research04 May 1995
Nature

Volume: 375, P: 54-58
Environmental Release Permits

Charles I Beck
Thomas H. Ulrich
Research01 Dec 1993
Bio/Technology

Volume: 11, P: 1524-1528
Interplay between an ATP-binding cassette F protein and the ribosome from Mycobacterium tuberculosis

The authors present structures of the MtbEttA protein bound to or free of the ribosome from Mycobacterium tuberculosis under different nucleotide states, which provide insights into the mechanism of translational regulation by EttA-like proteins.

Zhicheng Cui
Xiaojun Li
Junjie Zhang
ResearchOpen Access21 Jan 2022
Nature Communications

Volume: 13, P: 1-12
A direct test of density wave theory in a grand-design spiral galaxy

Information on stellar populations of the grand-design spiral galaxy UGC 3825 is exploited to measure the offset between young stars of a known age and the spiral arm in which they formed. The measured offset is consistent with a quasi-stationary density wave.

Thomas G. Peterken
Michael R. Merrifield
Kyle B. Westfall
Research12 Nov 2018
Nature Astronomy

Volume: 3, P: 178-182
Blood Coagulation Changes Following Hypoxemia in the Near-Term Fetal Lamb

C Thomas Kisker
Jean E Robillard
William R Clarke
Research01 Sept 1982
Pediatric Research

Volume: 16, P: 732-739
Macromolecular modeling and design in Rosetta: recent methods and frameworks

This Perspective reviews tools developed over the past five years in the macromolecular modeling, docking and design software Rosetta.

Julia Koehler Leman
Brian D. Weitzner
Richard Bonneau
Reviews01 Jun 2020
Nature Methods

Volume: 17, P: 665-680
Broadly neutralizing antibodies from human survivors target a conserved site in the Ebola virus glycoprotein HR2–MPER region

Cross-neutralizing antibodies from human survivors of the West Africa Ebola outbreak target a conserved membrane-proximal region in the virus glycoprotein HR2–MPER, which can be used as an immunogen to elicit neutralizing antibodies in rabbits.

Andrew I. Flyak
Natalia Kuzmina
James E. Crowe Jr
Research07 May 2018
Nature Microbiology

Volume: 3, P: 670-677
RosBREED: bridging the chasm between discovery and application to enable DNA-informed breeding in rosaceous crops

Amy F. Iezzoni
Jim McFerson
Cameron Peace
ReviewsOpen Access01 Nov 2020
Horticulture Research

Volume: 7, P: 1-23
Artificial intelligence for the detection of COVID-19 pneumonia on chest CT using multinational datasets

Chest CT is emerging as a valuable diagnostic tool for clinical management of COVID-19 associated lung disease. Here, the authors present a multinational study on the application of deep learning algorithms for COVID-19 diagnosis against multiple lung conditions as controls.

Stephanie A. Harmon
Thomas H. Sanford
Baris Turkbey
ResearchOpen Access14 Aug 2020
Nature Communications

Volume: 11, P: 1-7
Site-specific incorporation of nitroxide spin-labels into 2′-positions of nucleic acids

Thomas E Edwards
Snorri Th Sigurdsson
Protocols09 Aug 2007
Nature Protocols

Volume: 2, P: 1954-1962
Seasonal and regional presence of hymenopteran parasitoids of Drosophila in Switzerland and their ability to parasitize the invasive Drosophila suzukii

Valery Knoll
Thomas Ellenbroek
Jana Collatz
ResearchOpen Access18 Jan 2017
Scientific Reports

Volume: 7, P: 1-11
Genome-wide DNA-(de)methylation is associated with Noninfectious Bud-failure exhibition in Almond (Prunus dulcis [Mill.] D.A.Webb)

Jonathan Fresnedo-Ramírez
Helen M. Chan
Thomas M. Gradziel
ResearchOpen Access16 Feb 2017
Scientific Reports

Volume: 7, P: 1-12
The Glasgow Outcome Scale — 40 years of application and refinement

The Glasgow Outcome Scale (GOS) is widely recommended as an outcome measure after traumatic brain injury. Following the 40^thanniversary of its original publication, McMillan and colleagues review the development of the GOS and its extension and refinement over the past four decades, and consider how it can contribute to further understanding of brain injury.

Tom McMillan
Lindsay Wilson
Michael Bond
Reviews15 Jul 2016
Nature Reviews Neurology

Volume: 12, P: 477-485
Pedigree analysis of 220 almond genotypes reveals two world mainstream breeding lines based on only three different cultivars

Felipe Pérez de los Cobos
Pedro J. Martínez-García
Ignasi Batlle
ResearchOpen Access01 Jan 2021
Horticulture Research

Volume: 8, P: 1-11
Decellularization and antibody staining of mouse tissues to map native extracellular matrix structures in 3D

Surgical techniques are presented that facilitate decellularization of various mouse tissues. Immunostaining and microscopy of the resulting tissues is also presented using an extracellular matrix–specific antibody catalog.

Alejandro E Mayorca-Guiliani
Oliver Willacy
Raphael Reuten
Protocols08 Nov 2019
Nature Protocols

Volume: 14, P: 3395-3425
Understanding the emergence of modern humans and the disappearance of Neanderthals: Insights from Kaldar Cave (Khorramabad Valley, Western Iran)

Behrouz Bazgir
Andreu Ollé
Eudald Carbonell
ResearchOpen Access02 Mar 2017
Scientific Reports

Volume: 7, P: 1-16
An electric-eel-inspired soft power source from stacked hydrogels

Miniature hydrogel compartments in scalable stacked and folded geometries were used to prepare a contact-activated artificial electric organ.

Thomas B. H. Schroeder
Anirvan Guha
Michael Mayer
Research14 Dec 2017
Nature

Volume: 552, P: 214-218
A guide to analysis of mouse energy metabolism

Authors present workflows for the analysis of metabolism phenotypes in mice and recommend analysis of covariance to asses body composition effects.

Matthias H Tschöp
John R Speakman
Eric Ravussin
Reviews28 Dec 2011
Nature Methods

Volume: 9, P: 57-63
Somatic alterations in circulating cell-free DNA of oesophageal carcinoma patients during primary staging are indicative for post-surgical tumour recurrence

Helen Pasternack
Jana Fassunke
Hakan Alakus
ResearchOpen Access08 Oct 2018
Scientific Reports

Volume: 8, P: 1-8
Functional connectivity signatures of NMDAR dysfunction in schizophrenia—integrating findings from imaging genetics and pharmaco-fMRI

Arnim J. Gaebler
Nilüfer Fakour
Klaus Mathiak
ResearchOpen Access16 Feb 2023
Translational Psychiatry

Volume: 13, P: 1-12
Role of BNIP3 and NIX in cell death, autophagy, and mitophagy

J Zhang
P A Ney
Reviews20 Feb 2009
Cell Death & Differentiation

Volume: 16, P: 939-946

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