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Showing 1–5 of 5 results
Advanced filters: Author: Thomas Prod'homme Clear advanced filters

  • A variety of immune cell types contribute to disease in individuals with multiple sclerosis, an autoimmune condition of the central nervous system. Thomas Prod'homme and Scott Zamvil comment on the 'Bench to Bedside' approach, examining how recent basic research implicates the antigen-presenting cell in this disease. In our 'Bedside to Bench' column, Hans Link explores how recent clinical trials may bolster a mechanistic role for the B cell.

    • Thomas Prod'homme
    • Scott S Zamvil
    News & Views
    Nature Medicine
    Volume: 14, P: 614-615

  • Statins are best known for their cholesterol-lowering effects, but they also have immunomodulatory properties that might be exploited to treat neuroinflammatory disorders, such as multiple sclerosis. This review describes the molecular and cellular mechanisms that are thought to underlie the immunomodulatory effects, and discusses the results of initial clinical trials of statins in patients with multiple sclerosis.

    • Martin S Weber
    • Thomas Prod'homme
    • Scott S Zamvil
    Reviews
    Nature Clinical Practice Neurology
    Volume: 1, P: 106-112

  • Autoimmune brain inflammation is associated with activation of macrophages and microglia. Here the authors show that fibrinogen induces encephalitogenic T-cell activation and macrophage recruitment to the central nervous system, and promotes demyelination in a mouse model of multiple sclerosis.

    • Jae Kyu Ryu
    • Mark A. Petersen
    • Katerina Akassoglou
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-15

  • Findings from a mouse model of multiple sclerosis suggest that regulatory T cells alone cannot outduel pathogenic T cells in the central nervous system. The observations may have implications for experimental approaches designed to dampen autoimmune diseases by infusion of regulatory T cells (pages 423–431).

    • Thomas Prod'homme
    • Martin S Weber
    • Scott S Zamvil
    News & Views
    Nature Medicine
    Volume: 13, P: 411-413