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Showing 1–2 of 2 results
Advanced filters: Author: Thomas Reygaerts Clear advanced filters

  • Gain-of-function variants in the gene encoding NLRP3 lead to constitutive inflammasome activation and excessive IL-1β production. In this resource, authors perform functional screening of clinically relevant NLRP3 variants. Structural analysis suggested multiple mechanisms by which variants activate NLRP3 and the identification of pathogenic variants that can sensitize the activation of NLRP3 in response to nigericin and cold temperature exposure.

    • Shouya Feng
    • Matthew C. Wierzbowski
    • Seth L. Masters
    ResearchOpen Access
    Nature Immunology
    Volume: 26, P: 511-523

  • This Review from Masters and colleagues highlights how damage to intracellular organelles is linked to activation of the innate immune system. The authors propose that a better appreciation of such organellar homeostasis could lead to the identification of novel innate immune pathways and have therapeutic implications.

    • Cassandra R. Harapas
    • Elina Idiiatullina
    • Seth L. Masters
    Reviews
    Nature Reviews Immunology
    Volume: 22, P: 535-549