Nature Search

Ulcerative colitis mucosal transcriptomes reveal mitochondriopathy and personalized mechanisms underlying disease severity and treatment response

The severity of ulcerative colitis, and response to treatment, is highly variable. Here, the authors examine rectal gene expression signatures and faecal microbiomes of children and adults with the disease and provide new insights in to pathogenesis.

Yael Haberman
Rebekah Karns
Lee A. Denson
ResearchOpen Access03 Jan 2019
Nature Communications

Volume: 10, P: 1-13
A selective USP1–UAF1 inhibitor links deubiquitination to DNA damage responses

Deubiquitinases (DUBs) are peptidases that remove ubiquitin from post-translationally modified proteins. The identification of a selective small-molecule inhibitor of the USP1–UAF1 deubiquitination complex reveals a role for deubiquitination in regulating the DNA damage response.

Qin Liang
Thomas S Dexheimer
Zhihao Zhuang
Research16 Feb 2014
Nature Chemical Biology

Volume: 10, P: 298-304
Single cell transcriptomic analysis of HPV16-infected epithelium identifies a keratinocyte subpopulation implicated in cancer

The role of keratinocyte subpopulations in the different phases of the viral cycle during HPV16 infection remains to be characterised. Here, single cell RNA sequencing of HPV16 infected and uninfected organoids identifies 12 distinct keratinocyte populations including an HPV-reprogrammed keratinocyte subpopulation that is linked to cancer.

Mary C. Bedard
Tafadzwa Chihanga
Susanne I. Wells
ResearchOpen Access08 Apr 2023
Nature Communications

Volume: 14, P: 1-20
Suppression of the FOXM1 transcriptional programme via novel small molecule inhibition

Overexpression of the FOXM1 transcription factor occurs in several cancer and correlates with poor prognoses. Here, the authors identify a novel small molecule capable of displacing FOXM1 from its DNA consensus motif in vitro, displace it from target promoters and downregulate the expression of its target genes cancer cells.

Michael V. Gormally
Thomas S. Dexheimer
Shankar Balasubramanian
Research12 Nov 2014
Nature Communications

Volume: 5, P: 1-11
Measurement of the mass difference and the binding energy of the hypertriton and antihypertriton

The STAR collaboration reports a measurement of the mass difference and binding energy of the hypertriton and its antiparticle. This work constrains the hyperon–nucleon interaction and allows us to test the CPT theorem in a nucleus with strangeness.

J. Adam
L. Adamczyk
M. Zyzak
Research09 Mar 2020
Nature Physics

Volume: 16, P: 409-412
Clinical phenotype of germline RUNX1 haploinsufficiency: from point mutations to large genomic deletions

Mylène Béri-Dexheimer
Véronique Latger-Cannard
Philippe Jonveaux
Research14 May 2008
European Journal of Human Genetics

Volume: 16, P: 1014-1018
Hyperphosphorylated tau aggregation and cytotoxicity modulators screen identified prescription drugs linked to Alzheimer's disease and cognitive functions

Mengyu Liu
Thomas Dexheimer
Min-Hao Kuo
ResearchOpen Access06 Oct 2020
Scientific Reports

Volume: 10, P: 1-14
Age-of-diagnosis dependent ileal immune intensification and reduced alpha-defensin in older versus younger pediatric Crohn Disease patients despite already established dysbiosis

Yael Haberman
Melanie Schirmer
Lee A. Denson
Research12 Dec 2018
Mucosal Immunology

Volume: 12, P: 491-502
Identifying chemopreventive agents for obesity-associated cancers using an efficient, 3D high-throughput transformation assay

Vanessa Benham
Blair Bullard
Jamie J. Bernard
ResearchOpen Access16 Jul 2019
Scientific Reports

Volume: 9, P: 1-12
DNA cleavage assay for the identification of topoisomerase I inhibitors

Thomas S Dexheimer
Yves Pommier
Protocols16 Oct 2008
Nature Protocols

Volume: 3, P: 1736-1750
The Genomics Research and Innovation Network: creating an interoperable, federated, genomics learning system

Kenneth D. Mandl
Tracy Glauser
Yu Zhang
ResearchOpen Access04 Sept 2019
Genetics in Medicine

Volume: 22, P: 371-380
Correction: The Genomics Research and Innovation Network: creating an interoperable, federated, genomics learning system

Kenneth D. Mandl
Tracy Glauser
Yu Zhang
Amendments and CorrectionsOpen Access27 Nov 2019
Genetics in Medicine

Volume: 22, P: 449

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Ulcerative colitis mucosal transcriptomes reveal mitochondriopathy and personalized mechanisms underlying disease severity and treatment response

A selective USP1–UAF1 inhibitor links deubiquitination to DNA damage responses

Single cell transcriptomic analysis of HPV16-infected epithelium identifies a keratinocyte subpopulation implicated in cancer

Suppression of the FOXM1 transcriptional programme via novel small molecule inhibition

Measurement of the mass difference and the binding energy of the hypertriton and antihypertriton

Clinical phenotype of germline RUNX1 haploinsufficiency: from point mutations to large genomic deletions

Hyperphosphorylated tau aggregation and cytotoxicity modulators screen identified prescription drugs linked to Alzheimer's disease and cognitive functions

Age-of-diagnosis dependent ileal immune intensification and reduced alpha-defensin in older versus younger pediatric Crohn Disease patients despite already established dysbiosis

Identifying chemopreventive agents for obesity-associated cancers using an efficient, 3D high-throughput transformation assay

DNA cleavage assay for the identification of topoisomerase I inhibitors

The Genomics Research and Innovation Network: creating an interoperable, federated, genomics learning system

Correction: The Genomics Research and Innovation Network: creating an interoperable, federated, genomics learning system

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