The authors report that rat brain glutamatergic synaptic vesicles express monovalent cation/H+ exchangers that convert the Δψ of the proton electrochemical gradient into Δψ. They find that this K+/H+ exchange stimulates the accumulation of glutamate into vesicles, regulating glutamate release and thus synaptic transmission.
- Germaine Y Goh
- Hai Huang
- Robert H Edwards
