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Showing 1–7 of 7 results
Advanced filters: Author: Thomas von Erlach Clear advanced filters

  • Self-assembly of small drugs with organic dyes represents a facile route to synthesize nanoparticles with high drug-loading capability. Here the authors combine a machine learning approach with high-throughput experimental validation to identify which combinations of drugs and excipient lead to successful nanoparticle formation and characterize the therapeutic efficacy of two of them in vitro and in animal models.

    • Daniel Reker
    • Yulia Rybakova
    • Giovanni Traverso
    Research
    Nature Nanotechnology
    Volume: 16, P: 725-733

  • Matrix metalloproteinase enzymes are widely known to contribute to the breakdown of tissues. Here, the authors utilise a biomaterial substrate functionalised with a laminin fragment to modulate the expression of these enzymes, subsequently controlling the integrity of tissue.

    • Christine-Maria Horejs
    • Jean-Philippe St-Pierre
    • Molly M. Stevens
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-15

  • An ingestible, flexible piezoelectric sensor that senses mechanical deformations in the gastric cavity allows for the monitoring of ingestion states in the gastrointestinal tract of pigs.

    • Canan Dagdeviren
    • Farhad Javid
    • Giovanni Traverso
    Research
    Nature Biomedical Engineering
    Volume: 1, P: 807-817

  • The use of drug delivery systems for the gastrointestinal tract has been faced with a number of drawbacks related to their prolonged use. Here, the authors develop a drug-loaded hydrogel with high strength to withstand long-term gastrointestinal motility and can be triggered to dissolve on demand.

    • Jinyao Liu
    • Yan Pang
    • Giovanni Traverso
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-10