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Showing 1–7 of 7 results
Advanced filters: Author: Thorsten E. Boroviak Clear advanced filters

  • Why do human embryos need a yolk sac and how does it form? This Perspective by Thorsten Boroviak and Connor Ross explores the development and function of the yolk sac in primate embryogenesis.

    • Connor Ross
    • Thorsten E. Boroviak
    ReviewsOpen Access
    Nature Communications
    Volume: 11, P: 1-14

  • 3D transcriptomes reveal the molecular code of lineage specification in the primate embryo and provide an in vivo reference to decipher human development.

    • Sophie Bergmann
    • Christopher A. Penfold
    • Thorsten E. Boroviak
    Research
    Nature
    Volume: 609, P: 136-143

  • Mammalian embryogenesis relies on glycolysis and oxidative phosphorylation, but understanding of the dynamics of metabolic regulation in the postimplantation embryo in vivo remains elusive. Here the authors compile single-cell embryo profiling data in six mammalian species and reveal a conserved metabolic programme despite different implantation modes.

    • Anna Malkowska
    • Christopher Penfold
    • Thorsten E. Boroviak
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-12

  • The mechanical microenvironment influences stem cell pluripotency. Here, the authors culture stem cells in microgels with controlled volumetric confinement and identify Plakoglobin as a mechanoresponsive regulator of pluripotency in mouse and human.

    • Timo N. Kohler
    • Joachim De Jonghe
    • Florian Hollfelder
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-19

  • Stat3 depletion in pluripotent cells decreases α-ketoglutarate and increases the expression of Otx2 and its targets Dnmt3a and Dnmt3b, leading to global DNA hypermethylation.

    • Riccardo M. Betto
    • Linda Diamante
    • Graziano Martello
    Research
    Nature Genetics
    Volume: 53, P: 215-229

  • It has been unclear at which stage of mouse development embryonic stem cells can be derived. Nichols and colleagues use single-cell cultures to demonstrate that derivation of cells able to proliferate without ERK signalling (a characteristic of ESCs) is limited to the early pre-implantation epiblast and is favoured by culture on a laminin substrate.

    • Thorsten Boroviak
    • Remco Loos
    • Jennifer Nichols
    Research
    Nature Cell Biology
    Volume: 16, P: 513-525

  • Bergmann et al. discuss the construction of synthetic uteri to model the earliest stages of human embryogenesis and associated pathologies. They highlight the constituent components from which a synthetic uterus may be engineered, propose a modular approach to assembling synthetic uteri and discuss how these technologies can shed light on implantation failure and uterine pathologies.

    • Sophie Bergmann
    • Magdalena Schindler
    • Thorsten E. Boroviak
    ReviewsOpen Access
    Communications Biology
    Volume: 4, P: 1-12