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Showing 1–4 of 4 results
Advanced filters: Author: Tia A. Tummino Clear advanced filters

  • Tummino et al. dock 74 million molecules against the human cannabinoid-1 receptor to find uM ligands. Optimization led to a nM agonist conferring analgesia with reduced side effects in mice, highlighting its potential as a pain therapeutic and the promise of a structure-based approach.

    • Tia A. Tummino
    • Christos Iliopoulos-Tsoutsouvas
    • Brian K. Shoichet
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-19

  • Using a multi-OMICS approach, Haas et al identify 54 human genes and 16 host-targeting chemical compounds that regulate influenza A virus infection in lung epithelial cells, including AHNAK and COBP1 which are also essential for SARS-CoV-2 infection.

    • Kelsey M. Haas
    • Michael J. McGregor
    • Nevan J. Krogan
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-27

  • A human–SARS-CoV-2 protein interaction map highlights cellular processes that are hijacked by the virus and that can be targeted by existing drugs, including inhibitors of mRNA translation and predicted regulators of the sigma receptors.

    • David E. Gordon
    • Gwendolyn M. Jang
    • Nevan J. Krogan
    Research
    Nature
    Volume: 583, P: 459-468

  • Crystal structures of the σ2 receptor are determined and used to perform a docking screen of nearly 500 million molecules, identifying σ2-selective ligands and providing insight into the role of σ2 in neuropathic pain.

    • Assaf Alon
    • Jiankun Lyu
    • Andrew C. Kruse
    Research
    Nature
    Volume: 600, P: 759-764