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A genome-wide association study identifies a novel susceptibility locus for the immunogenicity of polyethylene glycol

Some individuals develop antibodies against the polyethylene glycol that is commonly used in therapeutic preparations. Here the authors conduct a GWAS in Han Chinese and find the IGH locus is associated with anti-PEG IgM.

Chia-Jung Chang
Chien-Hsiun Chen
Jer-Yuarn Wu
ResearchOpen Access12 Sept 2017
Nature Communications

Volume: 8, P: 1-7
To generate functional anti-protease-activated receptor-4 (PAR4), a G protein-coupled receptor, antibodies through PAR4-mRNA-LNP immunization

En-Shuo Liu
Kai-Wen Ho
Tian-Lu Cheng
ResearchOpen Access20 Nov 2025
npj Vaccines

Volume: 10, P: 1-10
Using anti-poly(ethylene glycol) bioparticles for the quantitation of PEGylated nanoparticles

Yuan-Chin Hsieh
Ta-Chun Cheng
Tian-Lu Cheng
ResearchOpen Access19 Dec 2016
Scientific Reports

Volume: 6, P: 1-9
Conditional internalization of PEGylated nanomedicines by PEG engagers for triple negative breast cancer therapy

The majority of treatment options for cancers are ineffective due to limited therapeutic targeting. Here, the authors develop bispecific antibodies that effectively target nanomaterials to triple-negative breast cancer cell receptors and deliver therapeutics leading to inhibition of tumour growth.

Yu-Cheng Su
Pierre-Alain Burnouf
Steve R. Roffler
ResearchOpen Access08 Jun 2017
Nature Communications

Volume: 8, P: 1-12
Use of syngeneic cells expressing membrane-bound GM-CSF as an adjuvant to induce antibodies against native multi-pass transmembrane protein

Chien-Chiao Huang
Kai-Wen Cheng
Tian-Lu Cheng
ResearchOpen Access09 Jul 2019
Scientific Reports

Volume: 9, P: 1-11
Enhancement of tumor tropism of mPEGylated nanoparticles by anti-mPEG bispecific antibody for ovarian cancer therapy

Wen-Wei Lin
Yi-An Cheng
Tian-Lu Cheng
ResearchOpen Access07 Apr 2021
Scientific Reports

Volume: 11, P: 1-12
Selective activation of pro-anti-IL-1β antibody enhances specificity for autoinflammatory disorder therapy

Wen-Wei Lin
Yun-Chi Lu
Tian-Lu Cheng
ResearchOpen Access21 Jul 2021
Scientific Reports

Volume: 11, P: 1-10
Selective antibody activation through protease-activated pro-antibodies that mask binding sites with inhibitory domains

I-Ju Chen
Chih-Hung Chuang
Shey-Cherng Tzou
ResearchOpen Access14 Sept 2017
Scientific Reports

Volume: 7, P: 1-12
A molecular dynamics simulation study decodes the Zika virus NS5 methyltransferase bound to SAH and RNA analogue

Chih-Hung Chuang
Shean-jaw Chiou
Yeng-Tseng Wang
ResearchOpen Access20 Apr 2018
Scientific Reports

Volume: 8, P: 1-9
Structural determination of an antibody that specifically recognizes polyethylene glycol with a terminal methoxy group

Methoxy polyethylene glycol (mPEG) is widely attached to drug molecules to improve their therapeutic efficacy, however mPEG can induce anti-PEG antibodies that negatively impact their therapeutic effects. Here, the authors determine the co-crystal structure of the humanized 15-2b anti-mPEG antibody with mPEG, providing insights into understanding mPEG-binding specificity and antigenicity of anti-mPEG antibodies.

Minh-Tram T. Nguyen
Yu-Chien Shih
Yu-Cheng Su
ResearchOpen Access01 Aug 2022
Communications Chemistry

Volume: 5, P: 1-8
Nucleic acid drug vectors for diagnosis and treatment of brain diseases

Zhi-Guo Lu
Jie Shen
Xin Zhang
ReviewsOpen Access17 Jan 2023
Signal Transduction and Targeted Therapy

Volume: 8, P: 1-53
Hapten-directed targeting to single-chain antibody receptors

Tian-Lu Cheng
Kuang-Wen Liao
Steve R Roffler
Research26 Mar 2004
Cancer Gene Therapy

Volume: 11, P: 380-388

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