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Showing 1–4 of 4 results
Advanced filters: Author: Tiancai Chang Clear advanced filters

  • Cysteinyl leukotriene receptor CysLT2R can be activated by cysteinyl leukotrienes LTC4, LTD4 and LTE4, and is associated with various inflammatory diseases. Here, authors present cryo-EM structures of CysLT2R-Gq bound to LTC4 and LTD4, which are characterized as ago-allosteric modulators of CysLT2R.

    • Mu Li
    • Xiaoling Bao
    • Heng Liu
    ResearchOpen Access
    Nature Communications
    Volume: 17, P: 1-12

  • GPR99 self-activation is promoted by the second extracellular loop (ECL2) occupying the orthosteric pocket, which is stabilized by a water-mediated polar network. These findings provide a structural basis for this receptor’s physiological roles and a theoretical framework for designing drugs targeting the receptor.

    • Miaofang Xiao
    • Xiaoling Bao
    • Heng Liu
    ResearchOpen Access
    Communications Biology
    Volume: 9, P: 1-9

  • In this study the authors present the Thogoto virus polymerase cryo-EM structures and reveal unique RNA synthesis mechanisms among orthomyxoviruses. RNA synthesis by Thogoto virus polymerase is shown to be weakly dependent on the host factors ANP32A/B/E in human cells in contrast to influenza viruses.

    • Lu Xue
    • Tiancai Chang
    • Xiaoli Xiong
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-16

  • Optical nonreciprocity through magneto-optical effects requires bulky apparatuses and strong magnetic fields, while magnetic-free approaches are difficult to implement. Here, the authors use optically-induced magnetisation in an atomic ensemble to get 50 dB of isolation over a large power dynamic range.

    • Xin-Xin Hu
    • Zhu-Bo Wang
    • Chang-Ling Zou
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-8