Tuft cells constitutively express IL-25 to sustain ILC2 homeostasis in the intestine, but mechanisms driving IL-25 secretion have been unclear. Here, Feng et al. find that tuft cells express IL-17RB, which is required to regulate the bioavailability of IL-25 and to restrain the activation of ILC2s during homeostasis.
- Xiaogang Feng
- Tilde Andersson
- Christoph Schneider
