Strategies to increase T cell infiltration within the tumor microenvironment could improve response to immune checkpoint blockade. Here the authors show that a combinatorial regimen based on Flt3L, radiotherapy, and TLR3/CD40 stimulation promotes intratumoral conventional type-1 dendritic cell (cDC1) activation and T cell infiltration, overcoming resistance to PD-L1 blockade.
- Takaaki Oba
- Mark D. Long
- Fumito Ito
