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Showing 1–2 of 2 results
Advanced filters: Author: Tiing Jen Loh Clear advanced filters

  • CD4+ T cells recognising shared susceptibility epitope (SE) encoded HLA-DRB1 presenting citrullinated self-peptides are implicated in rheumatoid arthritis. Here the authors characterise the T cell receptor repertoire and structure during recognition of different citrullinated self-epitopes in HLA-DR4 transgenic mice and ACPA + RA patients.

    • Tiing Jen Loh
    • Jia Jia Lim
    • Jamie Rossjohn
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-17

  • T cell receptors co-recognizing both MHC and antigenic peptide for a tri-party specific interaction has been a central dogma of T cell-mediated responses. Here the authors use X-ray crystallography to identify a TCR that contacts only the MHC beta chain of HLA-DQ2, with this specificity potentially enforced by Leucine-55 of HLA-DQ2.5 to exclude interaction with other MHCs.

    • Jia Jia Lim
    • Claerwen M. Jones
    • Jamie Rossjohn
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-15