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Showing 1–11 of 11 results
Advanced filters: Author: Tilman Flock Clear advanced filters

  • Extensive mutant cycle analysis provides a map of the residues that contribute to stability and activation-associated conformational dynamics of the Gαi1 protein in nucleotide-bound states and in complex with the G protein–coupled receptor rhodopsin.

    • Dawei Sun
    • Tilman Flock
    • Dmitry B Veprintsev
    Research
    Nature Structural & Molecular Biology
    Volume: 22, P: 686-694

  • Nonselective engagement of GPCR signaling pathways by GPCR-targeting drugs can reduce treatment efficacy and cause side effects. The authors show that signaling selectivity in CB2R can be tuned by reshaping allosteric networks, offering insights for more precise therapies.

    • Adrian Morales-Pastor
    • Tamara Miljuš
    • Jana Selent
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-14

  • Analysis of 18 available structures and other data reveals a new, conserved structural motif in arrestins and suggests that different phosphorylation patterns of the GPCR C terminus can drive distinct arrestin conformations and functional outcomes.

    • Andrija Sente
    • Raphael Peer
    • Tilman Flock
    Research
    Nature Structural & Molecular Biology
    Volume: 25, P: 538-545

  • The cellular functions of arrestins are determined in part by the pattern of phosphorylation on the G protein-coupled receptors (GPCRs) to which arrestins bind. Here, authors use a library of synthetic phosphopeptide analogues of the GPCR rhodopsin C-terminus and determine the ability of these peptides to bind and activate arrestins using a variety of biochemical and biophysical methods.

    • Daniel Mayer
    • Fred F. Damberger
    • Dmitry B. Veprintsev
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-14

  • The identification of the positions and patterns of amino acids that form the selectivity determinants for the entire human G-protein and G-protein-coupled receptor signalling system.

    • Tilman Flock
    • Alexander S. Hauser
    • M. Madan Babu
    Research
    Nature
    Volume: 545, P: 317-322

  • There are ∼800 human GPCRs and 16 different Gα proteins; this study revealed the molecular details of Gα activation by GPCRs and suggests that a universal activation mechanism governs Gα activation—the details of this mechanism can explain how the GPCR–Gα system diversified rapidly, while conserving the allosteric activation mechanism.

    • Tilman Flock
    • Charles N. J. Ravarani
    • M. Madan Babu
    Research
    Nature
    Volume: 524, P: 173-179

  • The Protein Contacts Atlas is an interactive resource of non-covalent contacts that can generate multiple representations of non-covalent contacts from PDB structures at different scales, from atoms to subunits and entire complexes.

    • Melis Kayikci
    • A. J. Venkatakrishnan
    • M. Madan Babu
    Research
    Nature Structural & Molecular Biology
    Volume: 25, P: 185-194

  • An interactive online resource integrated in the GPCRdb hub presents tools to design GPCR constructs and determine appropriate experimental conditions for structural studies by crystallography and cryo-EM.

    • Christian Munk
    • Eshita Mutt
    • David E. Gloriam
    Reviews
    Nature Methods
    Volume: 16, P: 151-162