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Showing 251–300 of 322 results

Advanced filters: Author: Tim Hochberg Clear advanced filters

A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer

Rosalind Eeles, Christopher Haiman and colleagues report genome-wide association and meta-analyses of prostate cancer in populations of European, African, Japanese and Latino ancestry. They identify 23 new susceptibility loci, including one associated with early-onset prostate cancer.

Ali Amin Al Olama
Zsofia Kote-Jarai
Christopher A Haiman
Research14 Sept 2014
Nature Genetics

Volume: 46, P: 1103-1109
A large-scale genome-wide study of gene-sleep duration interactions for blood pressure in 811,405 individuals from diverse populations

Pavithra Nagarajan
Thomas W. Winkler
Heming Wang
Research04 Apr 2025
Molecular Psychiatry

Volume: 30, P: 3660-3672
A viral Sm-class RNA base-pairs with mRNAs and recruits microRNAs to inhibit apoptosis

Herpesvirus saimiri expresses a small nuclear RNA named HSUR2, with which it recruits two cellular microRNAs to repress specific mRNA targets and thereby inhibit apoptosis in infected T cells.

Carlos Gorbea
Tim Mosbruger
Demián Cazalla
Research04 Oct 2017
Nature

Volume: 550, P: 275-279
Epigenome-wide association study of body mass index, and the adverse outcomes of adiposity

A large-scale epigenome-wide association study identifies changes in DNA methylation associated with body mass index in blood and adipose tissue, and correlates DNA methylation sites with high risk of incident type 2 diabetes.

Simone Wahl
Alexander Drong
John C. Chambers
Research21 Dec 2016
Nature

Volume: 541, P: 81-86
PRC1 coordinates timing of sexual differentiation of female primordial germ cells

The Polycomb repressive complex 1 (PRC1) is found to have important gene-dosage-dependent and sex-specific roles in primordial germ cell (PGC) development, including the maintenance of high levels of Oct4 and Nanog and ensuring the proper timing of meiosis through the suppression of retinoic acid signalling in female PGCs.

Shihori Yokobayashi
Ching-Yeu Liang
Antoine H. F. M. Peters
Research13 Mar 2013
Nature

Volume: 495, P: 236-240
Tip60 is a haplo-insufficient tumour suppressor required for an oncogene-induced DNA damage response

The acetyl-transferase Tip60 regulates transcription and is involved in the DNA damage response. Now, work from a mouse model and in-human tumours provides evidence that Tip60 is a tumour suppressor gene, and suggests that Tip60 functions in an oncogene-induced DNA damage response that restrains early tumourigenesis.

Chiara Gorrini
Massimo Squatrito
Bruno Amati
Research30 Aug 2007
Nature

Volume: 448, P: 1063-1067
The Hippo kinases LATS1 and 2 control human breast cell fate via crosstalk with ERα

Ablation of the large tumour suppressor kinases 1 and 2 promotes a luminal breast cell phenotype through stabilization of oestrogen receptor-α, thereby changing human breast cell fate.

Adrian Britschgi
Stephan Duss
Mohamed Bentires-Alj
Research09 Jan 2017
Nature

Volume: 541, P: 541-545
Ornithine decarboxylase (ODC1) gene variant (rs2302615) is associated with gastric cancer independently of Helicobacter pylori CagA serostatus

Anna K. Miller
Gloria Tavera
Douglas R. Morgan
Research10 Aug 2021
Oncogene

Volume: 40, P: 5963-5969
Associations of the oral microbiota and Candida with taste, smell, appetite and undernutrition in older adults

Kristina S. Fluitman
Tim J. van den Broek
Bart J. F. Keijser
ResearchOpen Access01 Dec 2021
Scientific Reports

Volume: 11, P: 1-11
Helicobacter pylori infection associates with fecal microbiota composition and diversity

Fabian Frost
Tim Kacprowski
Markus M. Lerch
ResearchOpen Access27 Dec 2019
Scientific Reports

Volume: 9, P: 1-10
SRSF3 maintains transcriptome integrity in oocytes by regulation of alternative splicing and transposable elements

Dang Vinh Do
Bernhard Strauss
M. Azim Surani
ResearchOpen Access19 Jun 2018
Cell Discovery

Volume: 4, P: 1-16
Intestinal barrier function in morbid obesity: results of a prospective study on the effect of sleeve gastrectomy

Jennifer Wilbrink
Nienke Bernards
Ad Masclee
Research09 Dec 2019
International Journal of Obesity

Volume: 44, P: 368-376
Moving beyond neurons: the role of cell type-specific gene regulation in Parkinson’s disease heritability

Regina H. Reynolds
Juan Botía
Mina Ryten
ResearchOpen Access17 Apr 2019
npj Parkinson's Disease

Volume: 5, P: 1-14
Pharmacogenomic landscape of the Thai population from genome sequencing of 949 individuals

Jittima Piriyapongsa
Supatat Chumnumwat
Sissades Tongsima
ResearchOpen Access28 Dec 2024
Scientific Reports

Volume: 14, P: 1-14
Cortical changes associated with an anterior cruciate ligament injury may retrograde skilled kicking in football: preliminary EEG findings

Daghan Piskin
Gjergji Cobani
Jochen Baumeister
ResearchOpen Access16 Jan 2025
Scientific Reports

Volume: 15, P: 1-17
Identification of small molecules that interfere with c-di-GMP signaling and induce dispersal of Pseudomonas aeruginosa biofilms

Jens Bo Andersen
Louise Dahl Hultqvist
Tim Tolker-Nielsen
ResearchOpen Access09 Jul 2021
npj Biofilms and Microbiomes

Volume: 7, P: 1-13
Consistency of noncognitive skills and their relation to educational outcomes in a UK cohort

Tim T. Morris
George Davey Smith
Neil M. Davies
ResearchOpen Access05 Nov 2021
Translational Psychiatry

Volume: 11, P: 1-10
Molecular subtype-specific efficacy of anti-EGFR therapy in colorectal cancer is dependent on the chemotherapy backbone

Sanne ten Hoorn
Dirkje W. Sommeijer
Louis Vermeulen
ResearchOpen Access12 Jul 2021
British Journal of Cancer

Volume: 125, P: 1080-1088
Inferring causal molecular networks: empirical assessment through a community-based effort

The HPN-DREAM community challenge assessed the ability of computational methods to infer causal molecular networks, focusing specifically on the task of inferring causal protein signaling networks in cancer cell lines.

Steven M Hill
Laura M Heiser
Sach Mukherjee
ResearchOpen Access22 Feb 2016
Nature Methods

Volume: 13, P: 310-318
Subtype-specific genomic alterations define new targets for soft-tissue sarcoma therapy

Samuel Singer and colleagues report an integrative genomic analysis of soft-tissue sarcomas. They survey sequence, copy number and mRNA expression in 207 individuals diagnosed with one of seven major high-grade sarcoma subtypes, and highlight subtype-specific alternations.

Jordi Barretina
Barry S Taylor
Samuel Singer
Research04 Jul 2010
Nature Genetics

Volume: 42, P: 715-721
Multi-omic analysis of chronic myelomonocytic leukemia monocytes reveals metabolic and immune dysregulation leading to altered macrophage polarization

Hasse M. Addinsell
Rachel Cant
Kiran Batta
ResearchOpen Access15 Jan 2025
Leukemia

Volume: 39, P: 770-774
Exploratory analysis of the human breast DNA methylation profile upon soymilk exposure

Louis Coussement
Selin Bolca
Tim De Meyer
ResearchOpen Access11 Sept 2018
Scientific Reports

Volume: 8, P: 1-11
Mild atopic dermatitis is characterized by increase in non-staphylococcus pathobionts and loss of specific species

Lize Delanghe
Ilke De Boeck
Julie Leysen
ResearchOpen Access10 Oct 2024
Scientific Reports

Volume: 14, P: 1-10
Secondary-type mutations do not impact outcome in NPM1-mutated acute myeloid leukemia – implications for the European LeukemiaNet risk classification

Jan-Niklas Eckardt
Marius Bill
Christoph Röllig
ResearchOpen Access07 Sept 2023
Leukemia

Volume: 37, P: 2282-2285
Beta-containing bivalent SARS-CoV-2 protein vaccine elicits durable broad neutralization in macaques and protection in hamsters

Berry, Pavot et al. test a vaccine with sequences of the spike protein of the Beta and ancestral variants to overcome immune escape by new SARS-CoV-2 variants. They show in animal models the vaccine successfully expands the breadth and duration of antibody neutralization of several variants and offers protection to some variants.

Catherine Berry
Vincent Pavot
Valerie Lecouturier
ResearchOpen Access26 May 2023
Communications Medicine

Volume: 3, P: 1-16
Molecular genetic overlap between migraine and major depressive disorder

Yuanhao Yang
Huiying Zhao
Dale R. Nyholt
Research11 Jul 2018
European Journal of Human Genetics

Volume: 26, P: 1202-1216
Loss of TIP60 (KAT5) abolishes H2AZ lysine 7 acetylation and causes p53, INK4A, and ARF-independent cell cycle arrest

Johannes Wichmann
Catherine Pitt
Anne K. Voss
ResearchOpen Access20 Jul 2022
Cell Death & Disease

Volume: 13, P: 1-13
Profiling placental DNA methylation associated with maternal SSRI treatment during pregnancy

Amy M. Inkster
Chaini Konwar
Wendy P. Robinson
ResearchOpen Access30 Dec 2022
Scientific Reports

Volume: 12, P: 1-14
Bacterial plasmid-associated and chromosomal proteins have fundamentally different properties in protein interaction networks

Tim Downing
Alexander Rahm
ResearchOpen Access10 Nov 2022
Scientific Reports

Volume: 12, P: 1-14
Oncostatin M receptor-dependent signaling assessed by RNA sequencing in mouse hematopoietic stem cells

Logan S. Schwartz
Ruth L. Saxl
Jennifer J. Trowbridge
ResearchOpen Access12 Sept 2024
Scientific Data

Volume: 11, P: 1-8
Elevated plasma bile acids coincide with cardiac stress and inflammation in young Cyp2c70^−/− mice

Hilde D. de Vries
Tim R. Eijgenraam
Jan Freark de Boer
ResearchOpen Access02 Oct 2024
Pediatric Research

Volume: 97, P: 2145-2152
Exercise induces dynamic changes in intra-articular metabolism and inflammation associated with remodeling of the infrapatellar fat pad in mice

Timothy M. Griffin
Ravi K. Komaravolu
Ronald K. June
ResearchOpen Access18 Jan 2025
Scientific Reports

Volume: 15, P: 1-18
Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk

Richard Houlston and colleagues report a genome-wide association study for colorectal cancer. They report three loci newly associated with colorectal cancer, bringing the total number of common susceptibility loci to 20.

Malcolm G Dunlop
Sara E Dobbins
Richard S Houlston
Research27 May 2012
Nature Genetics

Volume: 44, P: 770-776
Assessing the perceived effect of non-pharmaceutical interventions on SARS-Cov-2 transmission risk: an experimental study in Europe

Giuseppe Alessandro Veltri
Janina Isabel Steinert
George Gaskell
ResearchOpen Access28 Feb 2024
Scientific Reports

Volume: 14, P: 1-9
High-throughput anaerobic screening for identifying compounds acting against gut bacteria in monocultures or communities

The authors describe a high-throughput screening strategy that can be carried out anaerobically for studying the effects of drugs in vitro on individual gut microbes or microbial communities created synthetically or obtained from stool samples.

Patrick Müller
Jacobo de la Cuesta-Zuluaga
Lisa Maier
Protocols13 Dec 2023
Nature Protocols

Volume: 19, P: 668-699
Early postnatal development of pyramidal neurons across layers of the mouse medial prefrontal cortex

Tim Kroon
Eline van Hugte
Rhiannon M. Meredith
ResearchOpen Access25 Mar 2019
Scientific Reports

Volume: 9, P: 1-16
Classification of electrophysiological and morphological neuron types in the mouse visual cortex

Gouwens et al. established a morpho-electrical taxonomy of cell types for the mouse visual cortex via unsupervised clustering analysis of multiple quantitative features from 1,938 neurons available online at the Allen Cell Types Database.

Nathan W. Gouwens
Staci A. Sorensen
Christof Koch
Research17 Jun 2019
Nature Neuroscience

Volume: 22, P: 1182-1195
Wood cookstove use is associated with gastric cancer in Central America and mediated by host genetics

Samara B. Rifkin
Anna K. Miller
Douglas R. Morgan
ResearchOpen Access02 Oct 2023
Scientific Reports

Volume: 13, P: 1-9
Maternal educational attainment in pregnancy and epigenome-wide DNA methylation changes in the offspring from birth until adolescence

Priyanka Choudhary
Giulietta S. Monasso
Sylvain Sebert
ResearchOpen Access05 Dec 2023
Molecular Psychiatry

Volume: 29, P: 348-358
Transcriptome analysis of dominant-negative Brd4 mutants identifies Brd4-specific target genes of small molecule inhibitor JQ1

Tim-Michael Decker
Michael Kluge
Dirk Eick
ResearchOpen Access10 May 2017
Scientific Reports

Volume: 7, P: 1-9
Comparison of Oxford Nanopore Technologies and Illumina MiSeq sequencing with mock communities and agricultural soil

Bo Maxwell Stevens
Tim B. Creed
Daniel K. Manter
ResearchOpen Access08 Jun 2023
Scientific Reports

Volume: 13, P: 1-11
Towards data-driven biopsychosocial classification of non-specific chronic low back pain: a pilot study

Scott D. Tagliaferri
Patrick J. Owen
Daniel L. Belavy
ResearchOpen Access12 Aug 2023
Scientific Reports

Volume: 13, P: 1-17
Chronic back pain sub-grouped via psychosocial, brain and physical factors using machine learning

Scott D. Tagliaferri
Tim Wilkin
Daniel L. Belavy
ResearchOpen Access07 Sept 2022
Scientific Reports

Volume: 12, P: 1-15
Structural brain alterations associated with suicidal thoughts and behaviors in young people: results from 21 international studies from the ENIGMA Suicidal Thoughts and Behaviours consortium

Laura S. van Velzen
Maria R. Dauvermann
Lianne Schmaal
ResearchOpen Access07 Sept 2022
Molecular Psychiatry

Volume: 27, P: 4550-4560
Brain ageing in schizophrenia: evidence from 26 international cohorts via the ENIGMA Schizophrenia consortium

Constantinos Constantinides
Laura K. M. Han
Esther Walton
ResearchOpen Access09 Dec 2022
Molecular Psychiatry

Volume: 28, P: 1201-1209
Multi-Omic analyses characterize the ceramide/sphingomyelin pathway as a therapeutic target in Alzheimer’s disease

Complementary multi-omics approach, in silico metabolic flux, and neuroimaging analyses link the sphingolipid pathway to Alzheimer’s disease pathogenesis with therapeutic targets validated using behavioral assessments in amyloidogenic APP/PS1 mice.

Priyanka Baloni
Matthias Arnold
Rima Kaddurah-Daouk
ResearchOpen Access08 Oct 2022
Communications Biology

Volume: 5, P: 1-13
Tissue, age, sex, and disease patterns of matrisome expression in GTEx transcriptome data

Tim O. Nieuwenhuis
Avi Z. Rosenberg
Marc K. Halushka
ResearchOpen Access03 Nov 2021
Scientific Reports

Volume: 11, P: 1-14
Neutrophil degranulation interconnects over-represented biological processes in atrial fibrillation

Makiri Kawasaki
Eva R. Meulendijks
Joris R. de Groot
ResearchOpen Access03 Feb 2021
Scientific Reports

Volume: 11, P: 1-13
Carrying asymptomatic gallstones is not associated with changes in intestinal microbiota composition and diversity but cholecystectomy with significant dysbiosis

Fabian Frost
Tim Kacprowski
Markus M. Lerch
ResearchOpen Access23 Mar 2021
Scientific Reports

Volume: 11, P: 1-10
Cord blood metabolic signatures predictive of childhood overweight and rapid growth

Evangelos Handakas
Pekka Keski-Rahkonen
Oliver Robinson
ResearchOpen Access12 Jul 2021
International Journal of Obesity

Volume: 45, P: 2252-2260

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